GPM6B Membrane Protein Introduction

Introduction of GPM6B

Neuronal membrane glycoprotein M6-b (GPM6B) is a protein that in humans is encoded by the GPM6B gene. GPM6B gene expression may be regulated by MITF in melanocytic cells. Pseudogenes of this gene are located on chromosomes Y and 22. The neuronal membrane glycoprotein M6-b belongs to the proteolipid protein family, the members of which are expressed in most brain regions. They are considered to be involved in cellular housekeeping functions such as cell-to-cell communication and membrane trafficking. Neuronal membrane glycoprotein M6-b may also be involved in osteoblast differentiation. Alternate splicing leads to multiple transcript variants.

Basic Information of GPM6B
Protein Name	Neuronal membrane glycoprotein M6-b
Gene Name	GPM6B
Aliases	M6b, M6B
Organism	Homo sapiens (Human)
UniProt ID	Q13491
Transmembrane Times	4
Length (aa)	265
Sequence	MKPAMETAAEENTEQSQERKGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSREDCCTKF

Function of GPM6B Membrane Protein

Neuronal membrane glycoprotein M6-b is a novel component of the nodal Schwann cell microvilli. M6B is a four-transmembrane protein belonging to the proteolipid protein family which mediates intercellular contact and regulates membrane growth, composition, and targeting. In the CNS, M6B is expressed in neurons, oligodendrocytes, and astrocytes. M6B has been shown to cooperate with its paralogs proteolipid protein (PLP) and neuronal membrane glycoprotein M6A in regulating membrane growth of oligodendrocytes and neurons, respectively. Outside the nervous system, M6B plays a role in osteoblast differentiation by regulating actin cytoskeleton, ECM remodeling, and cell adhesion. M6B may be involved in neural development and regulation of osteoblast function and bone formation. Diseases associated with GPM6B include Rett syndrome and hypomyelinating leukodystrophy.

Fig.1 Interacting proteins for GPM6B gene.

Application of GPM6B Membrane Protein in Literature

Bang M.L., et al. Glial M6B stabilizes the axonal membrane at peripheral nodes of Ranvier. Glia. 2018, 66(4): 801-812. PubMed ID: 29282769

This article reveals that M6B is a Schwann cell microvilli component which preserves the structural integrity of peripheral nodes of Ranvier.
Dere E., et al. Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist. Behav Brain Res. 2015, 277: 254-63. PubMed ID: 24768641

Authors in this group use Gpm6b null mutant mice to search for behavioral functions of Gpm6b. The results show that Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a serotonergic challenge.
Drabek K., et al. GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release. J Bone Miner Res. 2011, 26(9): 2045-51. PubMed ID: 21638316

The article indicates that GPM6B controls cytoskeleton and matrix vesicle release and can be used as a novel regulator of osteoblast function and bone formation.
Charfi C., et al. Identification of GPM6B and GPM6B as potential new human lymphoid leukemia-associated oncogenes. Cell Oncol (Dordr). 2014, 37(3): 179-91. PubMed ID: 24916915

The article reveals that GPM6A and GPM6B may act as novel oncogenes in the development of human lymphoid leukemia-associated oncogenes.
Combes P., et al. PLP1 and GPM6B intragenic copy number analysis by MAPH in 262 patients with hypomyelinating leukodystrophies: Identification of one partial triplication and two partial deletions of PLP1. Neurogenetics. 2006, 7(1): 31-7. PubMed ID: 16416265

This article reports that copy number changes in GPM6B and intragenic duplications of PLP1 are very unlikely to be involved in the etiology of UHL.

GPM6B Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GPM6B antibody development services.

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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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