Effects of OA and Lipo-OAs on ALT, AST, and GGT levels in the mice with PM2.5 or PM2.5- and alcohol-induced inflammation in the liver.
This study explored the potential benefits of oleanolic acid liposomes (Lipo-OAs) in treating hepatitis induced by alcohol and fine particulate matter (PM2.5). The researchers utilized the evaporation sonication method to formulate Lipo-OAs from DSPC, cholesterol, and oleanolic acid (OA). Afterward, they examined the impact of OA and Lipo-OAs on liver function parameters, including ALT, AST, and GGT, in the presence of PM2.5 and alcohol or PM2.5 alone. The results revealed significantly elevated levels of ALT, AST, and GGT in the inflamed livers induced by PM2.5 and alcohol, or PM2.5 alone, compared to healthy livers. Following treatment with OA or Lipo-OAs, these enzyme levels were markedly reduced, with Lipo-OAs showing a stronger inhibitory effect. This study underscores the potential anti-inflammatory and reparative effects of Lipo-OAs for the treatment of PM2.5 and alcohol-induced liver injury, suggesting a promising avenue for further research and potential clinical applications.
Pubmed: https://pubmed.ncbi.nlm.nih.gov/35631694/
DOI: 10.3390/pharmaceutics14051108
Wei, Ching-Ting, et al. "Reparative efficacy of liposome-encapsulated oleanolic acid against liver inflammation induced by fine ambient particulate matter and alcohol in mice." Pharmaceutics 14.5 (2022): 1108.
For Research Use Only. Not For Clinical Use