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Drug delivery by vesicular system has overtaken the pre-existing drugs by improving therapeutic efficacy and by sustaining and controlling action. Ethosomes are novel carrier systems used for delivery of drugs possessing low penetration through the biological membrane, mainly skin. With years of experience and high-end technologies in dermal and transdermal drug delivery research, Creative Biolabs has successfully developed a series of innovative and diversified lipid-based drug delivery platforms to provide fast and convenient services for our worldwide customers. Now, we provide high-quality no matter individual ethosomes development services and commercial ethosomes products for our clients to help your project make great progress.
Ethosomes
Ethosomal drug delivery system is non-invasive and delivers the drug to the deep skin layers to the systemic circulation. They are soft, malleable vesicles composed mainly of phospholipids such as phosphatidylserine, phosphatidylcholine, ethanol (relatively high concentration) and water, possessing a wide range of sizes from tens of nanometres to microns. Drug delivery can be modulated by altering alcohol:water ratio. In detail, some preferred phospholipids are soya phospholipids and high concentration of alcohol (20-45%) in the formulation provides soft, flexible characteristics and stability to the vesicles and it also disrupts lipid bilayer structure of the skin results in an increase in the membrane permeability.
Fig.1 Schematic representation of the different types of lipid-based vesicular delivery systems.1,2
Therapeutic application
Ethosomes are able to penetrate the deeper layers of the skin and hence appear to be vesicles of choice for transdermal drug delivery of hydrophilic and impermeable drugs through the skin. Ethosomes are regarded as a non-invasive type of carriers that deliver drugs to deep skin layers and/or systemic circulation. Ethosomes are sophisticated, safe, and effective systems and easily prepared. Once any moiety is entrapped within the system, it is not exposed to metabolic degradation and dilution. These types of systems have a prolonged drug release improving the therapeutic benefit. Nowadays, ethosomes is widely used in the delivery of protein, DNA and other bioactive agents for the treatment of herpetic infection, AIDS, parkinsonian syndrome, diabetes and so forth.
What We Can Do for You?
Aided by our well-established platforms and experienced scientists, we can provide comprehensive ethosomes services, varying from lipid-based drug delivery characterization, delivery system construction services to in vitro efficacy validation, in vivo PK/PD validation. A wide spectrum of customized delivery products is available for your choice.
With expertise and dedication, advanced ethosomes design platforms and services from Creative Biolabs will be your best companion in preparing customized ethosomes. Please contact us for more information and a detailed quote.
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