The combination of PC and cholesterol enhances the stability and permeability of these liposomes, making them effective carriers for both hydrophilic and hydrophobic drugs. The cholesterol component helps in modulating the fluidity of the liposome bilayer, crucial for controlled release mechanisms.
These liposomes are commonly prepared using the thin-film hydration technique followed by extrusion or sonication to achieve uniform size distribution. This method ensures the encapsulation efficiency and reproducibility required for research and clinical applications.
Yes, these liposomes can be modified with targeting ligands or antibodies to facilitate targeted delivery. This allows the liposomes to selectively bind to specific cells or tissues, enhancing the therapeutic efficacy and reducing side effects.
While the inclusion of cholesterol generally enhances stability, these liposomes must be stored properly to maintain their structural integrity. They should be stored at 2-8°C and protected from light to prevent oxidation and degradation of lipids.
Beyond drug delivery, these liposomes are used in the study of lipid bilayer behavior, membrane-protein interactions, and as model systems for understanding cellular membrane dynamics. Their biocompatibility makes them ideal for physiological studies.
The encapsulation efficiencies and mean concentration-time profiles of SSa and SSd in the optimized SSa-SSd-Lip.
The goal of this work was to develop and optimize liposomes that delivered both saikosaponin a (SSa) and saikosaponin d (SSd) with enhanced bioavailability. Researchers employed response surface methodology to establish the optimal liposome formulation, with an EPC/drug ratio of 26.71 and an Egg PC/Chol ratio of 4. The encapsulation efficiencies of SSa and SSd for these liposomes were 86.19% and 79.87%, respectively (figure a). Subsequently, the pharmacokinetics of SSa-SSd-Lip were assessed. The results (figure b) showed that the AUC values for SSa and SSd in the SSa-SSd-Lip group were significantly higher than those in the SSa-SSd-sol group. This suggests that drug delivery via liposomes can prolong the drugs' half-life and enhance their bioavailability. This study used Egg PC:Chol liposomes as a co-delivery system for SSa and SSd, providing an optimized approach for co-delivering.
Pubmed: 25854754 DOI: 10.3390/molecules20045889
Zhang, Guo-Song, et al. "Formulations, hemolytic and pharmacokinetic studies on saikosaponin a and saikosaponin d compound liposomes." Molecules 20.4 (2015): 5889-5907.
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