The liposomes made from phosphatidylcholine (PC) lipids that are extracted from egg with cholesterol. Adding 30% cholesterol helps the liposomes stable.
Lipid Composition
Egg PC Cholesterol
Applications
Control liposomes, Membrane biology
Format
Liquid
Concentration
10mg/mL
Hydration Solution
PBS, pH 7.4
External Solution
PBS, pH 7.4
Storage
2°C - 8°C (do not freeze)
Size
100 nm
Shelf Life
6 months
Quantity
5mL (available in lyophilized powder)
Dosage
Download
DataSheet
MSDS
FAQsPublished Data Customer ReviewsRelated Sections
What makes Egg PC:Chol liposomes suitable for drug delivery?
The combination of PC and cholesterol enhances the stability and permeability of these liposomes, making them effective carriers for both hydrophilic and hydrophobic drugs. The cholesterol component helps in modulating the fluidity of the liposome bilayer, crucial for controlled release mechanisms.
How are Egg PC:Chol liposomes typically prepared?
These liposomes are commonly prepared using the thin-film hydration technique followed by extrusion or sonication to achieve uniform size distribution. This method ensures the encapsulation efficiency and reproducibility required for research and clinical applications.
Can Egg PC:Chol liposomes be used in targeted therapy?
Yes, these liposomes can be modified with targeting ligands or antibodies to facilitate targeted delivery. This allows the liposomes to selectively bind to specific cells or tissues, enhancing the therapeutic efficacy and reducing side effects.
What are the stability concerns with Egg PC:Chol liposomes?
While the inclusion of cholesterol generally enhances stability, these liposomes must be stored properly to maintain their structural integrity. They should be stored at 2-8°C and protected from light to prevent oxidation and degradation of lipids.
What research applications are Egg PC:Chol (70:30) liposomes commonly used for?
Beyond drug delivery, these liposomes are used in the study of lipid bilayer behavior, membrane-protein interactions, and as model systems for understanding cellular membrane dynamics. Their biocompatibility makes them ideal for physiological studies.
The encapsulation efficiencies and mean concentration-time profiles of SSa and SSd in the optimized SSa-SSd-Lip.
The goal of this work was to develop and optimize liposomes that delivered both saikosaponin a (SSa) and saikosaponin d (SSd) with enhanced bioavailability. Researchers employed response surface methodology to establish the optimal liposome formulation, with an EPC/drug ratio of 26.71 and an Egg PC/Chol ratio of 4. The encapsulation efficiencies of SSa and SSd for these liposomes were 86.19% and 79.87%, respectively (figure a). Subsequently, the pharmacokinetics of SSa-SSd-Lip were assessed. The results (figure b) showed that the AUC values for SSa and SSd in the SSa-SSd-Lip group were significantly higher than those in the SSa-SSd-sol group. This suggests that drug delivery via liposomes can prolong the drugs' half-life and enhance their bioavailability. This study used Egg PC:Chol liposomes as a co-delivery system for SSa and SSd, providing an optimized approach for co-delivering.
Zhang, Guo-Song, et al. "Formulations, hemolytic and pharmacokinetic studies on saikosaponin a and saikosaponin d compound liposomes." Molecules 20.4 (2015): 5889-5907.
Unparalleled Stability and Functionality
Creative Biolabs' Egg PC:Chol liposomes offer unparalleled stability and functionality, making them indispensable in our drug delivery research.
Essential for Neurological Studies
The composition of Egg PC:Chol liposomes facilitates crucial neurological studies, providing reliable results in targeted drug delivery to the brain.
Optimal for Vaccine Formulation
These liposomes are ideal for vaccine formulation, improving immunogenic responses due to their optimal cholesterol content.
Consistent Performance in Biocompatibility
Creative Biolabs ensures that their Egg PC:Chol liposomes maintain high biocompatibility, crucial for our sensitive in vivo studies.
Robust Delivery System for Proteins
These liposomes form a robust delivery system for protein-based therapies, ensuring stability and controlled release in physiological conditions.
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For Research Use Only. Not For Clinical Use