Hydrogenated Phosphatidylcholine

Phospholipid vesicles (liposomes) are often used in clinical applications, such as for drug delivery, and as biomembrane models. Hydrogenated phosphatidylcholine, as a member of phospholipids, can participate in the formation of liposomes and has important application prospects in drug delivery. With years of experience and high-end technologies, Creative Biolabs offers a wide range of phospholipid-based pharmaceutical formulations and liposome development services to customers worldwide. As a service provider, our goal is to provide the highest level of service, confidentiality and customer support.

Background of Hydrogenated Phosphatidylcholine

Nowadays, approximately 40% of newly developed active pharmaceutical ingredients are rejected during early development and bioavailability problems due to their poor water solubility make it difficult to be used in patients. Thus far, different efforts have been made to improve the solubility of drugs using a capable vehicle to enclose hydrophobic drugs, such as inclusion complexes with cyclodextrins, microemulsions, dendrimers or liposomes formulations. Of these complexes, liposomes are the most widely used carriers, which are formed by bilayer lipid membranes surrounding an aqueous core. Most of the phospholipids can form liposomes, of which phosphatidylcholine and hydrogenated phosphatidylcholine are the most studied and most commonly used.

Hydrogenated phosphatidylcholine (HPC) can be found in soy and eggs. Hydrogenated soy and egg phosphatidylcholine contain high levels of saturated fatty acids (particularly stearic acid, C18:0), with no polyunsaturated fatty acids. It is well known that phosphatidylcholine (PC) is easily oxidized due to its unsaturated fatty acid structure, resulting in poor stability under some conditions. However, the hydrogenation of PC produces HPC with higher oxidative stability and lower hygroscopicity, in the form of a white solid with improved color and less unpleasant odor.

The Hydrogenated Phosphatidylcholine in Drug Delivery

Phospholipid (PL) vesicles (Liposomes), which are closed vesicles of phospholipid bilayers or lamellae with enclosed aqueous layers and cores, are able to encapsulate hydrophobic and hydrophilic ingredients into their structure. PC is easily oxidized, and in some cases has lower stability, while HPC has the antioxidant capacity, so the preparation of liposomes with HPC improves the drug efficacy. Liposomes with HPC have significant performance in increasing encapsulation capacity and improving stability. Therefore, HPC instead of PC has an important role in pharmaceutical preparations.

In addition, as a delivery vehicle, HPC can form solid dispersions with some drugs, increasing the dissolution rate, solubility and bioavailability of poorly soluble drugs. As the particle size of the drug narrows and the relative surface area expands, the solubility of the drug can be improved by preparing an amorphous solid dispersion, and the bioavailability of the drug also improves owing to the optimized saturation solubility in gastrointestinal fluids.

Our Service about Hydrogenated Phosphatidylcholine

Based on the properties of HPC as a drug delivery vehicle, Creative Biolabs is capable of providing our global clients with the best customized formulations and services about HPC. Our services have the following advantages:

• Custom platform
• Seasoned technology
• One-stop pipeline
• High efficiency

As a leading provider in the field of biological research and drug discovery, Creative Biolabs has a team of Ph.D. scientists with extensive hands-on experience in basic and applied research to help clients achieve their goals. If you are interested in our services, please contact us for more details.

For Research Use Only. Not For Clinical Use