These liposomes are composed of DSPC, Cholesterol, DSPG, and DSPE-PEG. They are designed to enhance the stability and circulation time of drugs in the bloodstream, making them suitable for targeted drug delivery applications.
They are typically synthesized via thin-film hydration followed by extrusion, ensuring uniform size and unilamellar structure, which are crucial for drug release and targeting efficiency.
Incorporating DSPE-PEG(2000) enhances the stealth properties of the liposomes, minimizing immune system detection and extending their presence in the bloodstream.
Yes, these liposomes can be customized in terms of size, surface characteristics, and encapsulated agents to meet specific research requirements.
They are used in targeted drug delivery, particularly in cancer therapy, and for delivering genetic materials due to their enhanced biocompatibility and circulation time.
Characterization of liposomes with different lipid compositions.
This study compared the impact of different lipid compositions on liposomes. Researchers prepared three different mixed lipids (DOPC/Chol; DOPC/Chol/DSPG; DSPC/Chol/DSPG) into both PEGylated and non-PEGylated liposomes. They tested the size distribution, zeta potential, encapsulation efficiency (Figure A), drug release profiles (Figure B), and stability (Figure C) of each group of liposomes. The results showed that compared to non-PEGylated liposomes, PEGylated liposomes had smaller mean particle sizes, lower polydispersity indexes, less negative charge, and higher encapsulation efficiency. Additionally, PEGylated liposomes also exhibited better performance in drug release and stability. This study optimized the formulation of Shikonin liposomes, highlighting the advantages of PEGylation in various aspects, and providing valuable references for the optimization of formulations of other drug-loaded liposomes.
Tsermentseli, Stella K., et al. "Comparative study of PEGylated and conventional liposomes as carriers for shikonin." Fluids 3.2 (2018): 36. Under Open Access license CC BY 4.0, the image is a composite of figure 2, figure 3 and figure 4.
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