DSPC:Chol:DSPG:DSPE-PEG(2000) Liposomes

DSPC:Chol:DSPG:DSPE-PEG(2000) Liposomes (CAT#: LDLY-0123-LY98)

Description

Anionic liposomes demonstrate greater stability in solution. Polyethylene glycol (PEG) is a kind of sterically-stabilized, hydrophilic polymer, has been used to improve liposome stability and enhance their circulation times in the blood. Adding PEG to a neutral liposome will protect the liposomes from circulating proteins, improving their plasma clearance and enhancing their therapeutic effects.

Lipid Composition

DSPC
Cholesterol
DSPG
DSPE-mPEG2000

Applications

Control liposomes, Membrane biology

Format

Liquid

Concentration

10mg/mL

Hydration Solution

PBS, pH 7.4

External Solution

PBS, pH 7.4

Storage

2°C - 8°C (do not freeze)

Size

100 nm

Shelf Life

6 months

Quantity

5mL (available in lyophilized powder)

Dosage

Download

DataSheet

MSDS

FAQs Published Data Customer Reviews Related Sections

What is the purpose of DSPC:Chol:DSPG:DSPE-PEG(2000) liposomes?
These liposomes are composed of DSPC, Cholesterol, DSPG, and DSPE-PEG. They are designed to enhance the stability and circulation time of drugs in the bloodstream, making them suitable for targeted drug delivery applications.
How are DSPC:Chol:DSPG:DSPE-PEG(2000) liposomes synthesized?
They are typically synthesized via thin-film hydration followed by extrusion, ensuring uniform size and unilamellar structure, which are crucial for drug release and targeting efficiency.
What are the key advantages of including DSPE-PEG(2000) in the liposome formulation?
Incorporating DSPE-PEG(2000) enhances the stealth properties of the liposomes, minimizing immune system detection and extending their presence in the bloodstream.
Can DSPC:Chol:DSPG:DSPE-PEG(2000) liposomes be customized for specific research needs?
Yes, these liposomes can be customized in terms of size, surface characteristics, and encapsulated agents to meet specific research requirements.
What applications are DSPC:Chol:DSPG:DSPE-PEG(2000) liposomes used for in biomedical research?
They are used in targeted drug delivery, particularly in cancer therapy, and for delivering genetic materials due to their enhanced biocompatibility and circulation time.

DSPC:Chol:DSPG:DSPE-PEG(2000) (60:30:5:5) Liposomes-fig1

Characterization of liposomes with different lipid compositions.

This study compared the impact of different lipid compositions on liposomes. Researchers prepared three different mixed lipids (DOPC/Chol; DOPC/Chol/DSPG; DSPC/Chol/DSPG) into both PEGylated and non-PEGylated liposomes. They tested the size distribution, zeta potential, encapsulation efficiency (Figure A), drug release profiles (Figure B), and stability (Figure C) of each group of liposomes. The results showed that compared to non-PEGylated liposomes, PEGylated liposomes had smaller mean particle sizes, lower polydispersity indexes, less negative charge, and higher encapsulation efficiency. Additionally, PEGylated liposomes also exhibited better performance in drug release and stability. This study optimized the formulation of Shikonin liposomes, highlighting the advantages of PEGylation in various aspects, and providing valuable references for the optimization of formulations of other drug-loaded liposomes.

DOI: 10.3390/fluids3020036

Tsermentseli, Stella K., et al. "Comparative study of PEGylated and conventional liposomes as carriers for shikonin." Fluids 3.2 (2018): 36.

Optimal Stability for Prolonged Studies
Creative Biolabs' liposomes with DSPC:Chol:DSPG:DSPE-PEG(2000) offer optimal stability, enhancing the longevity of our pharmacokinetic studies.
Enhanced Circulation Time
These liposomes are designed for enhanced circulation time, proving essential in my systemic drug delivery research.
High Encapsulation Efficiency
The high encapsulation efficiency of these liposomes supports effective delivery of both hydrophilic and hydrophobic drugs in my research.
Polyethylene Glycol Advantages
The incorporation of PEG in these liposomes greatly improves their systemic administration efficiency in drug delivery studies.

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For Research Use Only. Not For Clinical Use

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