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Liposomes are a safer, more effective, and environmentally friendly drug delivery system since they are biodegradable. However, the benefits of biodegradability result in liposomes having a shorter circulation time. Polymers boost liposome stability in terms of enzymes, chemicals, pH, and the immune system, as well as confer various functionalities on the liposome, hence enhancing therapeutic effectiveness.
Polymer-modified liposomes retain the benefits of liposomes as drug delivery carriers and possess unique functionality from the polymers, such as targeting, long circulation, high stability, and responsive release.
The most popular polymer-modified liposomes are PEGylated liposomes, also referred to as "stealth liposomes", which are liposomes modified with polyethylene glycol (PEG). PEG's spatial barrier limits plasma protein aggregation and liposome clearance by RES. As a result, PEGylated liposomes have a prolonged blood circulation time, which varies in strength depending on the molecular weight and PEG concentration.
Polymer | Efficacy |
Polyethylene glycol (PEG) | Increases liposomal half-life and bioavailability. |
Chitosan | It inhibits liposome aggregation and prevents oxygen from entering the lipid-water interface. |
Carboxymethyl cellulose | Reduces liposome aggregation and increases stability. |
Polyvinyl alcohol (PVA) | Increases the circulation time of liposomes. |
Polyvinylpyrrolidone (PVP) | Increases liposome circulation time and minimizes drug leakage. |
Poly (carboxybetaine) (PCB) | In vivo, it exhibits excellent hydrophilic drug retention and prolonged circulation time. |
Hyaluronic acid (HA) | It inhibits opsonin adsorption to the liposome surface, prolonging circulation duration while increasing liposome-specific binding to CD44, which is overexpressed in tumor cells. |
Octylamine-graft-poly (aspartic) (PASP-g-C8) | Drug is released at pH=5.0. |
Lipid-poly (2-ethylacrylic acid) (PEAA-C10) | Drug is released at pH=4.5. |
R6H4-C18 | At pH=6.4, it enhances cellular uptake and promotes drug release. |
Poly(L-lysine) | Improves liposomes' stability in biological environments. |
poly (L-glutamic acid) | |
Alginate | Liposomes possess thermo-sensitive properties, which allow for controlled drug release. |
Atelocollagen | Protects liposomes from immunological reactions and promotes cellular uptake. |
By grafting or coating polymers onto the surface of liposomes, or inserting them into the phospholipid bilayer, Creative Biolabs can provide you with polymer-modified liposomes. Our advantages are listed below:
Fig.1 Multiple types of polymer-modified liposome.1,2
Creative Biolabs is dedicated to providing clients with high-quality, customized liposome development services. Whether you need assistance with formulation development, scale-up, or manufacturing, our team is here to help every step of the way. Please contact us immediately for more details on polymer-modified liposomes and how we can help elevate your project to a new level.
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