Polymer-modified Liposome Development Service
Liposomes are a safer, more effective, and environmentally friendly drug delivery system since they are biodegradable. However, the benefits of biodegradability result in liposomes having a shorter circulation time. Polymers boost liposome stability in terms of enzymes, chemicals, pH, and the immune system, as well as confer various functionalities on the liposome, hence enhancing therapeutic effectiveness.
Advantages of Polymer-modified Liposomes
Polymer-modified liposomes retain the benefits of liposomes as drug delivery carriers and possess unique functionality from the polymers, such as targeting, long circulation, high stability, and responsive release.
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Improved stability and decreased drug leakage: Polymers inhibit liposome aggregation and breakdown under certain conditions.
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Longer drug circulation time: The reticuloendothelial system (RES) recognizes and clears liposomes with reduced efficiency.
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Reduced lipid oxidation: Polymer layers minimize exposure to oxygen, resulting in less lipid oxidation.
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Increased biological membrane permeability: Liposomes permeate cells via paracellular or transcellular routes due to polymer modification.
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Targeted delivery: Targeting tumor-associated molecules such as folate receptors and CD44.
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Responsive release: Drugs are released under various conditions based on light, temperature, pH, and specific enzymes.
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Customizable functionality: By synthesizing different polymers, liposomes can exhibit a variety of properties and functionalities.
Optional Polymers for Liposome Surface Modification
The most popular polymer-modified liposomes are PEGylated liposomes, also referred to as "stealth liposomes", which are liposomes modified with polyethylene glycol (PEG). PEG's spatial barrier limits plasma protein aggregation and liposome clearance by RES. As a result, PEGylated liposomes have a prolonged blood circulation time, which varies in strength depending on the molecular weight and PEG concentration.
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Polymer
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Efficacy
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Polyethylene glycol (PEG)
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Increases liposomal half-life and bioavailability.
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Chitosan
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It inhibits liposome aggregation and prevents oxygen from entering the lipid-water interface.
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Carboxymethyl cellulose
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Reduces liposome aggregation and increases stability.
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Polyvinyl alcohol (PVA)
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Increases the circulation time of liposomes.
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Polyvinylpyrrolidone (PVP)
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Increases liposome circulation time and minimizes drug leakage.
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Poly (carboxybetaine) (PCB)
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In vivo, it exhibits excellent hydrophilic drug retention and prolonged circulation time.
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Hyaluronic acid (HA)
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It inhibits opsonin adsorption to the liposome surface, prolonging circulation duration while increasing liposome-specific binding to CD44, which is overexpressed in tumor cells.
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Octylamine-graft-poly (aspartic) (PASP-g-C8)
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Drug is released at pH=5.0.
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Lipid-poly (2-ethylacrylic acid) (PEAA-C10)
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Drug is released at pH=4.5.
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R6H4-C18
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At pH=6.4, it enhances cellular uptake and promotes drug release.
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Poly(L-lysine)
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Improves liposomes' stability in biological environments.
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poly (L-glutamic acid)
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Alginate
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Liposomes possess thermo-sensitive properties, which allow for controlled drug release.
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Atelocollagen
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Protects liposomes from immunological reactions and promotes cellular uptake.
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Why Choose Us?
By grafting or coating polymers onto the surface of liposomes, or inserting them into the phospholipid bilayer, Creative Biolabs can provide you with polymer-modified liposomes. Our advantages are listed below:
Fig.1 Multiple types of polymer-modified liposome.1
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Polymer customization services
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PEGylated lipids are directly used to prepare PEGylated liposomes
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Various modification methods: Grafting, coating, and inserting
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Polymer-coated liposomes: One layer of polymer, layer-by-layer polymer, crosslinked polymers
Creative Biolabs is dedicated to providing clients with high-quality, customized liposome development services. Whether you need assistance with formulation development, scale-up, or manufacturing, our team is here to help every step of the way. Please contact us immediately for more details on polymer-modified liposomes and how we can help elevate your project to a new level.
References
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Cao, Yifeng, Xinyan Dong, and Xuepeng Chen. "Polymer-modified liposomes for drug delivery: from fundamentals to applications." Pharmaceutics 14.4 (2022): 778.
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under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not For Clinical Use
