The product is a kind of neutral PEGylated liposome. Our liposomes contain three kinds of cationic, anionic and neutral subtypes. Neutral liposomes are generally non-toxic and relatively stable in serum. PEG has been proven to improve the stability of liposomes and increase the circulation time of liposomes in the blood. Therefore, PEGylated liposomes have enhanced tumor permeability and retention effect (EPR) and improved tumor uptake.
Lipid Composition
HSPC Cholesterol DSPE-mPEG2000
Applications
Control liposomes, Membrane biology
Format
Liquid
Concentration
10mg/mL
Hydration Solution
PBS, pH 7.4
External Solution
PBS, pH 7.4
Storage
2°C - 8°C (do not freeze)
Size
70-120 nm
Shelf Life
6 months
Quantity
5mL (available in lyophilized powder)
Dosage
Download
DataSheet
MSDS
FAQsPublished Data Customer ReviewsRelated Sections
What is the typical size range of HSPC:Chol:DSPE-mPEG2000 liposomes?
These liposomes generally have a small mean particle size of about 70-120 nm. This size range is optimal for many in vivo applications, where smaller liposomes may have enhanced tissue penetration and distribution properties.
What are the benefits of the PEGylation in these liposomes?
PEGylation, achieved with DSPE-mPEG2000, enhances the stability and circulation time of these liposomes in the bloodstream. This modification reduces the immune system clearance, thus potentially increasing the bioavailability of encapsulated drugs.
Can these liposomes encapsulate both hydrophilic and hydrophobic drugs?
Yes, due to their versatile lipid composition, these liposomes can encapsulate a wide range of drug molecules, including both hydrophilic and hydrophobic compounds. This makes them highly suitable for diverse drug delivery applications.
Are there specific applications or studies where these liposomes are particularly useful?
These liposomes are especially useful in studies involving targeted drug delivery, including cancer therapy, due to their ability to carry and release drugs at specific sites. The PEGylation helps in evading the host's immune system, allowing the liposomes to circulate longer in the bloodstream.
How is the quality of these liposomes assured?
The liposomes are produced under stringent conditions to ensure high purity and sterility. The production process includes steps such as sterile filtration, and they are generally provided in glass vials to maintain their integrity and quality during storage and handling.
Therapeutic effects of cisplatin/mifepristone co-encapsulated liposomes on cervical cancer in vivo and in vitro.
This study examined the therapeutic effects of co-encapsulated liposomes on cervical cancer both in vivo and in vitro. Researchers utilized HSPC:Chol:DSPE-mPEG2000 liposomes as carriers to co-encapsulate cisplatin (Cis) and mifepristone (MF), resulting in the formation of L-Cis/MF. The therapeutic effects of L-Cis/MF on HeLa cells and xenografts in nu/nu mice were investigated. Figure A demonstrates that drug-loaded liposomes induced higher levels of apoptosis compared to free drugs. Figure B shows that the tumor growth inhibition of drug-loaded liposomes was superior to that of free drugs, with L-Cis/MF exhibiting the most pronounced effect. This study presents an effective, stable, and sustained drug delivery strategy for cervical cancer treatment, demonstrating superior therapeutic outcomes both in vivo and in vitro.
Ledezma-Gallegos, Fabricio, et al. "Liposomes co-encapsulating cisplatin/mifepristone improve the effect on cervical cancer: in vitro and in vivo assessment." Pharmaceutics 12.9 (2020): 897.
Unmatched Circulation Time
Creative Biolabs' liposomes exhibit extended circulation times and enhanced stability, crucial for our long-term studies on targeted drug delivery.
Excellence in Drug Encapsulation
Thanks to their ability to effectively encapsulate both hydrophilic and hydrophobic compounds, these liposomes have been indispensable in our therapeutic agent delivery research.
A Key Tool in Targeted Therapies
The specialized composition of these liposomes significantly enhances the delivery of therapeutic agents to specific tissues, which is pivotal in our cancer therapy studies.
Leading Innovation with Creative Biolabs
Creative Biolabs' liposomes are a cornerstone in our pharmaceutical research, offering unique advantages in stability and payload protection.
Superior Performance in Research Applications
These HSPC:Chol:DSPE-mPEG2000 liposomes have consistently outperformed alternatives in terms of stability and payload delivery, essential for our cutting-edge biomedical research.
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For Research Use Only. Not For Clinical Use