Cardiolipin is an essential phospholipid. It is the only known dimeric phospholipid, and its unique structure plays a major role in maintaining the function of membrane-associated proteins in the mitochondria. Cardiolipin is negatively charged in physiological pH. The studies of pharmacological, toxicological, and therapeutic effects have shown that the incorporation of doxorubicin in cardiolipin liposomes improved the antitumor activity of doxorubicin.
Lipid Composition
18:1 Cardiolipin
Applications
Control liposomes, Membrane biology
Format
Liquid
Concentration
10mg/mL
Hydration Solution
PBS, pH 7.4
External Solution
PBS, pH 7.4
Storage
2°C - 8°C (do not freeze)
Size
100 nm
Shelf Life
6 months
Quantity
5mL (available in lyophilized powder)
Dosage
Download
DataSheet
MSDS
FAQsPublished Data Customer ReviewsRelated Sections
What are 18:1 cardiolipin liposomes and their significance in research?
18:1 cardiolipin liposomes are vesicles formed from cardiolipin with oleic acid chains, offering unique properties for mitochondrial targeting. Due to their composition, these liposomes are particularly useful in studies related to mitochondrial functions and apoptosis.
How do 18:1 cardiolipin liposomes differ from other liposomal formulations?
Unlike other phospholipids, cardiolipin has four fatty acid chains, which confer distinct biophysical properties to the liposomes. This includes influencing the curvature and stability of membranes, making 18:1 cardiolipin liposomes particularly suited for mimicking mitochondrial membranes.
What applications do 18:1 cardiolipin liposomes have in biomedical research?
These liposomes are employed in research focused on understanding mitochondrial diseases, drug delivery to mitochondria, and studying the role of lipids in apoptosis and other cell death pathways. Their unique lipid composition closely resembles that of mitochondrial membranes, making them ideal for such studies.
Can 18:1 cardiolipin liposomes be used for drug delivery systems?
Yes, due to their biocompatibility and ability to fuse with mitochondrial membranes, 18:1 cardiolipin liposomes are being explored as vehicles for targeted drug delivery, especially for drugs aimed at treating mitochondrial disorders or targeting apoptotic pathways.
What challenges are associated with using 18:1 cardiolipin liposomes in research?
The main challenges include their sensitivity to oxidation and hydrolysis due to the unsaturated nature of the oleic acid chains. Researchers must handle them carefully to prevent degradation and preserve their functional properties during experimental procedures.
Proposed impact of increased monounsaturated and decreased polyunsaturated cardiolipin on cytochrome c form and function
This study examines the influence of 18:1 cardiolipin (CL) liposomes on the structural and functional properties of cytochrome c, a mitochondrial protein crucial for apoptosis and electron transport. The research emphasizes the impact of CL's acyl chain saturation on cytochrome c's ability to transform into a peroxidase, which plays a pivotal role in programmed cell death. The findings suggest that the peroxidase activity of cytochrome c increases when associated with unsaturated cardiolipin variants like 18:1 cardiolipin liposomes, compared to its activity with saturated ones. The experimental results show a significant increase in peroxidase activity with unsaturated CL liposomes. Specifically, cytochrome c peroxidase activity increased approximately 50% when associated with 18:1 cardiolipin compared to saturated CL or cytochrome c alone. These results highlight the potential therapeutic implications of manipulating cardiolipin saturation in liposomes to regulate mitochondrial functions and apoptosis, particularly in diseases characterized by mitochondrial dysfunction. This study underscores the importance of cardiolipin's acyl chain composition in modulating the biological activities of mitochondrial proteins.
Wilkinson, J. A., Silvera, S., & LeBlanc, P. J. The effect of cardiolipin side chain composition on cytochrome c protein conformation and peroxidase activity. Physiological Reports. 2021, 9(5): e14772.
Enhanced Membrane Protein Studies
Creative Biolabs' 18:1 cardiolipin liposomes have enhanced our membrane protein studies by improving mitochondrial function simulation.
Superior Bioenergetics Modeling
These liposomes are vital for our bioenergetics research, providing a robust model system that mimics mitochondrial membranes.
Creative Biolabs' Precise Formulations
Creative Biolabs delivers highly precise 18:1 cardiolipin liposomes, crucial for our studies on cellular energy metabolism.
Exceptional Stability and Functionality
The stability and functionality of these liposomes are exceptional, making them indispensable in our cardiovascular research.
Creative Biolabs' Commitment to Research Excellence
Relying on Creative Biolabs for their specialized 18:1 cardiolipin liposomes has markedly enhanced the reproducibility of our experiments.
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For Research Use Only. Not For Clinical Use