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Magic™ Antibody Discovery - Human IL-12 R beta 1 / CD212 (24-540) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0852F)

Datasheet
This membrane protein is Human IL-12 R beta 1 / CD212 (33-683). It has been tested in SDS-PAGE, ELISA, SRP. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL-12 R beta 1 / CD212
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 83.5 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Cys 24 - Glu 540 (Accession # P42701-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, SRP
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • IL-12 R beta 1 / CD212
  • Full Name
  • interleukin 12 receptor subunit beta 1
  • Introduction
  • The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • CD212; IMD30; IL12RB; IL-12R-BETA1; interleukin-12 receptor subunit beta-1; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; cluster of differentiation 212; interleukin 12 receptor, beta 1; interleukin-12 receptor beta-1 chain

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