Magic™ Antibody Discovery - Human IL-8 / CXCL8 (28-99) Membrane Protein, Partial, -His tag (CAT#: MP0347F)

Name: Magic™ Antibody Discovery - Human IL-8 / CXCL8 (28-99) Membrane Protein, Partial, -His tag
SKU: MP0347F
Rating: 5 (1 reviews)

Datasheet

This membrane protein is Human IL-8 / CXCL8 (28-99). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

Host Species
Human

Target Protein
IL-8 / CXCL8

Protein Length
ECD

Molecular Weight
The protein has a calculated MW of 10.3 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Sequence
AA Ser 28 - Ser 99 (Accession # P10145-1).

Product Description

Activity
Yes

Application
SDS-PAGE, ELISA

Expression Systems
HEK293

Tag
His tag at the C-terminus

Protein Format
Soluble

Reconstitution
Please see Certificate of Analysis for specific instructions.

Endotoxin
<1.0 EU/μg by the LAL method

Purity
>90% as determined by SDS-PAGE.

Buffer
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

Target Protein
IL-8 / CXCL8

Full Name
C-X-C motif chemokine ligand 8

Introduction
The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.

Alternative Names
IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; SCYB8; interleukin-8; T-cell chemotactic factor; alveolar macrophage chemotactic factor I; beta endothelial cell-derived neutrophil activating peptide; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; emoctakin; granulocyte chemotactic protein 1; interleukin 8; lung giant cell carcinoma-derived chemotactic protein; lymphocyte derived neutrophil activating peptide; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; tumor necrosis factor-induced gene 1

Gene ID
3576

UniProt ID
P10145

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