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Magic™ Antibody Discovery - Human Integrin alpha V beta 6 (ITGAV&ITGB6) (31-992(ITGAV)&22-707(ITGB6)) Membrane Protein, Partial, -His Tag & Tag free (CAT#: MP0880F)

Datasheet
This membrane protein is Human Integrin alpha V beta 6 (ITGAV&ITGB6) (31-992(ITGAV)&22-707(ITGB6)). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Integrin alpha V beta 6 (ITGAV&ITGB6)
  • Protein Length
  • ECD
  • Molecular Weight
  • Calculated MW of 112.9 kDa (ITGAV) and 79.6 kDa (ITGB6). The non-reducing (NR) protein migrates as 80-90 kDa (ITGB6) and 130-150 kDa (ITGAV) respectively due to glycosylation.
  • Sequence
  • AA Phe 31 - Val 992 (ITGAV) & Gly 22 - Asn 707 (ITGB6) (Accession # NP_002201.1 (ITGAV) & AAI21179.1 (ITGB6)).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a His tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Integrin alpha V beta 6 (ITGAV&ITGB6)
  • Full Name
  • integrin subunit alpha V&integrin subunit beta 6
  • Introduction
  • The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.&This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • Integrin alpha V beta 6, ITGAV&ITGB6

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