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Magic™ Membrane Protein Human ABHD12 (Abhydrolase domain containing 12, lysophospholipase) Full Length (CAT#: MPC4612K) Made to Order

Datasheet
This product is a made-to-order Human ABHD12 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ABHD12
  • Protein Length
  • Full length
  • Protein Class
  • Receptor
  • TMD
  • 1
  • Sequence
  • MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEP
    RCAADAGMKRALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKL
    IFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWK
    NAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHV
    VTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTG
    VATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWF
    FLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAP
    ARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • ABHD12
  • Full Name
  • Abhydrolase domain containing 12, lysophospholipase
  • Introduction
  • This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
  • Alternative Names
  • ABHD12; PHARC; ABHD12A; BEM46L2; hABHD12; C20orf22; dJ965G21.2; lysophosphatidylserine lipase ABHD12; 2-arachidonoylglycerol hydrolase ABHD12; abhydrolase domain-containing protein 12; monoacylglycerol lipase ABHD12; oxidized phosphatidylserine lipase ABHD12; Abhydrolase domain containing 12, lysophospholipase

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