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Magic™ Membrane Protein Human ADGRB1 (Adhesion G protein-coupled receptor B1) Full Length (CAT#: MPC0003K) Made to Order

Datasheet
This product is a 173 kDa Human ADGRB1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ADGRB1
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 173 kDa
  • TMD
  • 7
  • Sequence
  • MRGQAAAPGPVWILAPLLLLLLLLGRRARAAAGADAGPGPEPCATLVQGK
    FFGYFSAAAVFPANASRCSWTLRNPDPRRYTLYMKVAKAPVPCSGPGRVR
    TYQFDSFLESTRTYLGVESFDEVLRLCDPSAPLAFLQASKQFLQMRRQQP
    PQHDGLRPRAGPPGPTDDFSVEYLVVGNRNPSRAACQMLCRWLDACLAGS
    RSSHPCGIMQTPCACLGGEAGGPAAGPLAPRGDVCLRDAVAGGPENCLTS
    LTQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCE
    GVLEEGRQCNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAP
    QTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLC
    NNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPE
    KQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYG
    GAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCS
    GPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDNFGAVIWKETPAGEVA
    AVRCPRNATGLILRRCELDEEGIAYWEPPTYIRCVSIDYRNIQMMTREHL
    AKAQRGLPGEGVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMTEIFRRA
    YYSPTPGDVQNFVQILSNLLAEENRDKWEEAQLAGPNAKELFRLVEDFVD
    VIGFRMKDLRDAYQVTDNLVLSIHKLPASGATDISFPMKGWRATGDWAKV
    PEDRVTVSKSVFSTGLTEADEASVFVVGTVLYRNLGSFLALQRNTTVLNS
    KVISVTVKPPPRSLRTPLEIEFAHMYNGTTNQTCILWDETDVPSSSAPPQ
    LGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADANMEKATLPSVT
    LIVGCGVSSLTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILI
    GQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAVTGHLRNRLIR
    KRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAA
    AVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWSSCVVLPLLALTW
    MSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVV
    DRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATIT
    GTLKRPSLPEEEKLKLAHAKGPPTNFNSLPANVSKLHLHGSPRYPGGPLP
    DFPNHSLTLKRDKAPKSSFVGDGDIFKKLDSELSRAQEKALDTSYVILPT
    ATATLRPKPKEEPKYSIHIDQMPQTRLIHLSTAPEASLPARSPPSRQPPS
    GGPPEAPPAQPPPPPPPPPPPPQQPLPPPPNLEPAPPSLGDPGEPAAHPG
    PSTGPSTKNENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQDLN
    RKLQHAAEKDKEVLGPDSKPEKQQTPNKRPWESLRKAHGTPTWVKKELEP
    LQPSPLELRSVEWERSGATIPLVGQDIIDLQTEV

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ADGRB1
  • Full Name
  • Adhesion G protein-coupled receptor B1
  • Introduction
  • Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.
  • Alternative Names
  • BAI1; GDAIF; brain-specific angiogenesis inhibitor 1; ADGRB1; Adhesion G protein-coupled receptor B1

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