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Magic™ Membrane Protein Human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1) Full Length (CAT#: MPC1147K) Made to Order

Datasheet
This product is a 110.2 kDa Human ATP2A1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ATP2A1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 110.2 kDa
  • TMD
  • 10
  • Sequence
  • MEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLW
    ELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIA
    NAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDI
    VEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAV
    NQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQ
    QKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAV
    ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS
    DKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDK
    PVRPGQYDGLVELATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVE
    KMNVFNTDVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSP
    AKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMAVIK
    EWGTGRDTLRCLALATRDTPPKREEMVLDDSARFLEYETDLTFVGVVGML
    DPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVAD
    RAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAM
    TGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEG
    RAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTD
    GLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVG
    AAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMA
    LSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYV
    DPLPMIFKLRALDLTQWLMVLKISLPVIGLDEILKFVARNYLEDPEDERR
    K

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ATP2A1
  • Full Name
  • ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
  • Introduction
  • This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.
  • Alternative Names
  • ATP2A1; ATP2A; SERCA1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; SR Ca(2+)-ATPase 1; calcium pump 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

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