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Magic™ Membrane Protein Human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1) Full Length (CAT#: MPC0985K) Made to Order

Datasheet
This product is a 134.6 kDa Human ATP2B1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ATP2B1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 134.6 kDa
  • TMD
  • 10
  • Sequence
  • MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQ
    ESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQ
    LVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGE
    TGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGG
    QVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHV
    KKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEK
    KDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKK
    KANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQ
    KRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKM
    MKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKV
    PEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALL
    GLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFS
    KGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICL
    AFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRA
    GITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEI
    EQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTN
    DGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYD
    SISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASL
    ALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAG
    EKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVF
    EGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMG
    TLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAEREL
    RRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEF
    RIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEM
    NKSATSSSPGSPLHSLETSL

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • 8xHis and Flag tag at the C-terminus
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ATP2B1
  • Full Name
  • ATPase plasma membrane Ca2+ transporting 1
  • Introduction
  • The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Alternative Names
  • PMCA1; PMCA1kb; plasma membrane calcium-transporting ATPase 1; ATPase, Ca++ transporting, plasma membrane 1; plasma membrane calcium pump; ATP2B1; ATPase plasma membrane Ca2+ transporting 1

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