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Magic™ Membrane Protein Human BCAM (Basal cell adhesion molecule (Lutheran blood group)) Expressed in NS0 for Antibody Discovery, Partial (41-428aa) (CAT#: MPX0336K)

Datasheet
This product is a 83.7 kDa Human BCAM membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • BCAM
  • Protein Length
  • Partial (41-428aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 83.7 kDa
  • TMD
  • 1
  • Sequence
  • VEVMRGKSVI
    LDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSP
    PYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEAT
    EVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNP
    EGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGR
    LDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPE
    YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQL
    SKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDS
    TPLGDGPMLSLSSITFDSNGTYVCEASL

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc and 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • BCAM
  • Full Name
  • Basal cell adhesion molecule (Lutheran blood group)
  • Introduction
  • This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • BCAM; AU; LU; CD239; MSK19; basal cell adhesion molecule; Auberger b antigen; B-CAM cell surface glycoprotein; B-cell adhesion molecule; F8/G253 antigen; Lutheran blood group variant LUGA; basal cell adhesion molecule (Lu and Au blood groups); Basal cell adhesion molecule (Lutheran blood group)

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