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Magic™ Membrane Protein Human CLEC4G (C-type lectin domain family 4 member G) Full Length (CAT#: MPC3383K) Made to Order

Datasheet
This product is a made-to-order Human CLEC4G membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLEC4G
  • Protein Length
  • Full length
  • Protein Class
  • Receptor
  • TMD
  • 1
  • Sequence
  • MDTTRYSKWGGSSEEVPGGPWGRWVHWSRRPLFLALAVLVTTVLWAVILS
    ILLSKASTERAALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQA
    QLQTTRAELGEAQAKLMEQESALRELRERVTQGLAEAGRGREDVRTELFR
    ALEAVRLQNNSCEPCPTSWLSFEGSCYFFSVPKTTWAAAQDHCADASAHL
    VIVGGLDEQGFLTRNTRGRGYWLGLRAVRHLGKVQGYQWVDGVSLSFSHW
    NQGEPNDAWGRENCVMMLHTGLWNDAPCDSEKDGWICEKRHNC

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • CLEC4G
  • Full Name
  • C-type lectin domain family 4 member G
  • Introduction
  • This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • CLEC4G; LP2698; UNQ431; DTTR431; LSECtin; C-type lectin superfamily 4, member G; liver and lymph node sinusoidal endothelial cell C-type lectin; C-type lectin domain family 4 member G

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