Magic™ Membrane Protein Human CNTNAP2 (Contactin associated protein 2) Expressed in NS0 for Antibody Discovery, Partial (29-1262aa) (CAT#: MPX0262K)

Name: Magic™ Membrane Protein Human CNTNAP2 (Contactin associated protein 2) Expressed in NS0 for Antibody Discovery, Partial (29-1262aa)
SKU: MPX0262K
Rating: 5 (1 reviews)

Datasheet

This product is a 138 kDa Human CNTNAP2 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
CNTNAP2

Protein Length
Partial (29-1262aa)

Protein Class
Cell adhesion

Molecular Weight
138 kDa

Sequence
PSTSQKCDEPLVSGLPHVAFSS
SSSISGSYSPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIAT
QGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVRHEL
QHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINFDGHVVLPYRF
RNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLN
LGSNQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRSMQHFR
TNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDL
ARRKKLEPSNVGNLSFSCVEPYTVPVFFNATSYLEVPGRLNQDLFSVSFQ
FRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSG
SGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGG
FLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSID
MCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCE
AYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVSHDLQMQTPV
VGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPD
GSPYTWWVGKANEKHYYWGGSGPGIQKCACGIERNCTDPKYYCNCDADYK
QWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLSVGPLRCQGDRNYWNA
ASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKEDFIKLEL
KSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDR
LPQQIRKAPTEGHTRLELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLE
ERAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTF
CNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEE
IRFSFSTTKAPCILLYISSFTTDFLAVLVKPTGSLQIRYNLGGTREPYNI
DVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSSSDTLFNSPK
SLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNQIAPLKAALRQTNAS
AHVHIQGELVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQG
QAIRNGVNRNSA

Product Description

Expression Systems
NS0

Tag
6xHis tag at the C-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 250 μg/mL in PBS.

Endotoxin
<0.10 EU per 1 μg of the protein by the LAL method.

Purity
>90%, by SDS-PAGE with silver staining

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.

Target

Target Protein
CNTNAP2

Full Name
Contactin associated protein 2

Introduction
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2, a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and intellectual disability.

Alternative Names
CNTNAP2; CDFE; NRXN4; AUTS15; CASPR2; PTHSL1; contactin-associated protein-like 2; cell recognition molecule Caspr2; contactin associated protein like 2; homolog of Drosophila neurexin IV; Contactin associated protein 2

Gene ID
26047

UniProt ID
Q9UHC6

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