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Magic™ Membrane Protein Human CNTNAP2 (Contactin associated protein 2) Expressed in NS0 for Antibody Discovery, Partial (29-1262aa) (CAT#: MPX0262K)

Datasheet
This product is a 138 kDa Human CNTNAP2 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CNTNAP2
  • Protein Length
  • Partial (29-1262aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 138 kDa
  • TMD
  • 1
  • Sequence
  • PSTSQKCDEPLVSGLPHVAFSS
    SSSISGSYSPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIAT
    QGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVRHEL
    QHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINFDGHVVLPYRF
    RNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLN
    LGSNQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRSMQHFR
    TNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDL
    ARRKKLEPSNVGNLSFSCVEPYTVPVFFNATSYLEVPGRLNQDLFSVSFQ
    FRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSG
    SGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGG
    FLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSID
    MCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCE
    AYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVSHDLQMQTPV
    VGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPD
    GSPYTWWVGKANEKHYYWGGSGPGIQKCACGIERNCTDPKYYCNCDADYK
    QWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLSVGPLRCQGDRNYWNA
    ASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKEDFIKLEL
    KSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDR
    LPQQIRKAPTEGHTRLELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLE
    ERAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTF
    CNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEE
    IRFSFSTTKAPCILLYISSFTTDFLAVLVKPTGSLQIRYNLGGTREPYNI
    DVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSSSDTLFNSPK
    SLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNQIAPLKAALRQTNAS
    AHVHIQGELVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQG
    QAIRNGVNRNSA

Product Description

  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 250 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE with silver staining
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • CNTNAP2
  • Full Name
  • Contactin associated protein 2
  • Introduction
  • This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2, a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and intellectual disability.
  • Alternative Names
  • CNTNAP2; CDFE; NRXN4; AUTS15; CASPR2; PTHSL1; contactin-associated protein-like 2; cell recognition molecule Caspr2; contactin associated protein like 2; homolog of Drosophila neurexin IV; Contactin associated protein 2

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