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Magic™ Membrane Protein Human HLA-DQB2 (Major histocompatibility complex, class II, DQ beta 2) Full Length (CAT#: MPC4162K) Made to Order

Datasheet
This product is a made-to-order Human HLA-DQB2 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • HLA-DQB2
  • Protein Length
  • Full length
  • Protein Class
  • Immunity
  • TMD
  • 1
  • Sequence
  • MSWKMALQIPGGFWAAAVTVMLVMLSTPVAEARDFPKDFLVQFKGMCYFT
    NGTERVRGVARYIYNREEYGRFDSDVGEFQAVTELGRSIEDWNNYKDFLE
    QERAAVDKVCRHNYEAELRTTLQRQVEPTVTISPSRTEALNHHNLLVCSV
    TDFYPAQIKVRWFRNDQEETAGVVSTSLIRNGDWTFQILVMLEITPQRGD
    IYTCQVEHPSLQSPITVEWRAQSESAQSKMLSGIGGFVLGLIFLGLGLII
    RHRGQKGPRGPPPAGLLH

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • HLA-DQB2
  • Full Name
  • Major histocompatibility complex, class II, DQ beta 2
  • Introduction
  • HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus.
  • Alternative Names
  • HLA-DQB2; DQB2; HLA-DXB; HLA-DQB1; HLA class II histocompatibility antigen, DQ beta 2 chain; DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB)); HLA class II histocompatibility antigen, DX beta chain; MHC class II antigen DQB2; Major histocompatibility complex, class II, DQ beta 2

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