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Magic™ Membrane Protein Human KCNQ1 (Potassium voltage-gated channel subfamily Q member 1) Full Length (CAT#: MPC0636K) Made to Order

Datasheet
This product is a 74.6 kDa Human KCNQ1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KCNQ1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 74.6 kDa
  • TMD
  • 6
  • Sequence
  • MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGAL
    YAPIAPGAPGPAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPV
    LARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAA
    LATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISI
    IDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRL
    LGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
    DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSG
    FALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAP
    RSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEE
    RRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGETLLTPI
    THISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHL
    NLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
    QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDP
    ELFLPSNTLPTYEQLTVPRRGPDEGS

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • KCNQ1
  • Full Name
  • Potassium voltage-gated channel subfamily Q member 1
  • Introduction
  • This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.
  • Alternative Names
  • LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated; potassium channel subunit alpha KvLQT1; kidney and cardiac voltage dependend K+ channel; potassium channel, voltage gated KQT-like subfamily Q, member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; slow delayed rectifier channel subunit; voltage-gated potassium channel subunit Kv7.1; KCNQ1; Potassium voltage-gated channel subfamily Q member 1

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