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Magic™ Membrane Protein Human NPC1L1 (NPC1 like intracellular cholesterol transporter 1) Full Length (CAT#: MPC1010K) Made to Order

Datasheet
This product is a 148.7 kDa Human NPC1L1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NPC1L1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 148.7 kDa
  • TMD
  • 13
  • Sequence
  • MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLM
    TLSNVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLE
    ASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQL
    PAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQ
    RWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVARCNESQGDD
    VATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTI
    LLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVAS
    WPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQH
    FGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQER
    LRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTL
    LLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPV
    FPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEM
    RAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLA
    LGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQ
    VVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLC
    SLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSK
    RQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFLLHWITRGVVL
    LLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPV
    YFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPA
    SSWVDDFIDWLTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGS
    VRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLDTVAI
    LSPRLEYSGTISAHCNLYLLDSTSRFMAYHKPLKNSQDYTEALRAARELA
    ANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPT
    FAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVS
    AVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPG
    ILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPAL
    ALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKGAGAISN
    FLPNNGRQF

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • NPC1L1
  • Full Name
  • NPC1 like intracellular cholesterol transporter 1
  • Introduction
  • The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • NPC1L1; LDLCQ7; NPC11L1; SLC65A2; NPC1-like intracellular cholesterol transporter 1; NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC1 like 1; niemann-Pick C1-like protein 1; NPC1 like intracellular cholesterol transporter 1

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