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Magic™ Membrane Protein Human PCDHGB4 (Protocadherin gamma subfamily B, 4) Full Length (CAT#: MPC3035K) Made to Order

Datasheet
This product is a made-to-order Human PCDHGB4 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PCDHGB4
  • Protein Length
  • Full length
  • Protein Class
  • Cell adhesion
  • TMD
  • 1
  • Sequence
  • MGSGAGELGRAERLPVLFLFLLSLFCPALCEQIRYRIPEEMPKGSVVGNL
    ATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKP
    ACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGT
    RFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLKTPL
    DREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVS
    LSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEIT
    VLNTLDFEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSL
    PNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSSRNTY
    KLVTDAVLDREQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVF
    SQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMASDLEQRELS
    SYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLV
    DDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNA
    WLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDGGQP
    PLSATATLHLVFADSLQEVLPDITDRPDPSDLQAELQFYLVVALALISVL
    FLVAMILAIALRLRRSSSPASWSCFQPGLCVKSESVVPPNYSEGTLPYSY
    NLCVAHTGKTEFNFLKCSEQLSSGQDILCGDSSGALFPLCNSSELTSHQQ
    APPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEA
    ADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAG
    KRDGKAPAGGNGNKKKSGKKEKK

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • PCDHGB4
  • Full Name
  • Protocadherin gamma subfamily B, 4
  • Introduction
  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes.
  • Alternative Names
  • PCDHGB4; FIB2; CDH20; PCDH-GAMMA-B4; protocadherin gamma-B4; cadherin 20; fibroblast cadherin FIB2; fibroblast cadherin-2; Protocadherin gamma subfamily B, 4

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