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Magic™ Membrane Protein Human PPM1L (Protein phosphatase, Mg2+/Mn2+ dependent 1L) Full Length (CAT#: MPC2578K) Made to Order

This product is a made-to-order Human PPM1L membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PPM1L
  • Protein Length
  • Full length
  • Protein Class
  • Protein phosphatase
  • TMD
  • 1
  • Sequence
  • MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVK
    SSRDAVKMVKGKVAEIMQNDRLGGLDVLEAEFSKTWEFKNHNVAVYSIQG
    RRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQH
    LQDYEKDKENSVLSYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALL
    SDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFIS
    FNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILA
    SDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVK
    FRNSSKTEEQ

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • PPM1L
  • Full Name
  • Protein phosphatase, Mg2+/Mn2+ dependent 1L
  • Introduction
  • The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • PPM1L; PP2CE; PPM1-LIKE; PP2C-epsilon; protein phosphatase 1L; PP2C epsilon; Protein phosphatase, Mg2+/Mn2+ dependent 1L

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