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Magic™ Membrane Protein Human RNF139 (Ring finger protein 139) Full Length (CAT#: MPC4297K) Made to Order

Datasheet
This product is a made-to-order Human RNF139 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • RNF139
  • Protein Length
  • Full length
  • Protein Class
  • Transferase
  • TMD
  • 12
  • Sequence
  • MAAVGPPQQQVRMAHQQVWAALEVALRVPCLYIIDAIFNSYPDSSQSRFC
    IVLQIFLRLFGVFASSIVLILSQRSLFKFYTYSSAFLLAATSVLVNYYAS
    LHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIHSI
    YSQLIILDLLVPVIGLITELPLHIRETLLFTSSLILTLNTVFVLAVKLKW
    FYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRVTAQA
    TVLMYILRMANETDSFFISWDDFWDLICNLIISGCDSTLTVLGMSAVISS
    VAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLI
    RLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLF
    ILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYY
    NVLWEKLDDYVYYVRSTGSIIEFIFGVVMFGNGAYTMMFESGSKIRAFMM
    CLHAYFNIYLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEINDVCAIC
    YHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSN
    VSNNNGFIPPNETPEEAVREAAAESDRELNEDDSTDCDDDVQRERNGVIQ
    HTGAAAEEFNDDTD

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • RNF139
  • Full Name
  • Ring finger protein 139
  • Introduction
  • The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
  • Alternative Names
  • RNF139; RCA1; TRC8; HRCA1; E3 ubiquitin-protein ligase RNF139; RING-type E3 ubiquitin transferase RNF139; multiple membrane spanning receptor TRC8; patched related protein translocated in renal cancer; translocation in renal carcinoma on chromosome 8 protein; translocation in renal carcinoma, chromosome 8; Ring finger protein 139

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