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Magic™ Membrane Protein Human SLC46A1 (Solute carrier family 46 member 1) Full Length (CAT#: MPC0862K) Made to Order

Datasheet
This product is a 49.7 kDa Human SLC46A1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SLC46A1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 49.7 kDa
  • TMD
  • 12
  • Sequence
  • MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHR
    FSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFS
    STLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRIL
    CALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGG
    HWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRS
    IVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
    SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFA
    FATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNS
    LAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHL
    EFQQFPQSP

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • SLC46A1
  • Full Name
  • Solute carrier family 46 member 1
  • Introduction
  • This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Alternative Names
  • G21; HCP1; PCFT; proton-coupled folate transporter; heme carrier protein 1; solute carrier family 46 (folate transporter), member 1; SLC46A1; Solute carrier family 46 member 1

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