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Magic™ Membrane Protein Human SORCS3 (Sortilin related VPS10 domain containing receptor 3) Expressed in NS0 for Antibody Discovery, Partial (134-1125aa) (CAT#: MPX0170K)

Datasheet
This product is a 112.1 kDa Human SORCS3 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SORCS3
  • Protein Length
  • Partial (134-1125aa)
  • Protein Class
  • Transporter
  • Molecular Weight
  • 112.1 kDa
  • TMD
  • 1
  • Sequence
  • AQPPITQERGDAWATAP
    ADGSRGSRPLAKGSREEVKAPRAGGSAAEDLRLPSTSFALTGDSAHNQAM
    VHWSGHNSSVILILTKLYDFNLGSVTESSLWRSTDYGTTYEKLNDKVGLK
    TVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGATYQKYRLTFYIQSL
    LFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVAGLDK
    EADLVHMEVRTTDGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEY
    IFIQVTTSGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAV
    QEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKG
    IFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHL
    HLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNT
    WRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTS
    VPLFVDGALVEAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKED
    YQTWHLLNQGEPCVMGERKIFKKRKPGAQCALGRDHSGSVVSEPCVCANW
    DFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNN
    CTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEG
    DLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLG
    SDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWW
    FGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNALIQDTKEIAVHEYF
    QSQLLSFSPNLDYHNPDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFP
    GLPTSAELFILPPKNLTERRKGNEGDLEQIVETLFNALNQNLVQFELKPG
    VQVIVYVTQLTLAPLVDSSAGHSSS

Product Description

  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.01 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • SORCS3
  • Full Name
  • Sortilin related VPS10 domain containing receptor 3
  • Introduction
  • This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing.
  • Alternative Names
  • SORCS3; SORCS; VPS10 domain-containing receptor SorCS3; VPS10 domain receptor protein SORCS 3 (SORCS3); Sortilin related VPS10 domain containing receptor 3

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