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Magic™ Membrane Protein Human TSHR (Thyroid stimulating hormone receptor) Expressed in CHO for Antibody Discovery, Partial (22-413aa) (CAT#: MPX0053K)

This product is a 71 kDa Human TSHR membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TSHR
  • Protein Length
  • Partial (22-413aa)
  • Protein Class
  • GPCR
  • Molecular Weight
  • 71 kDa
  • TMD
  • 7
  • Sequence
  • MGCSSPPCECHQEEDFRVTCKDIQRIPSL
    PPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNL
    SKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYST
    DIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGT
    KLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLK
    ELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM
    CNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNA
    HYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTP
    KSDEFNPCEDIMG

Product Description

  • Expression Systems
  • CHO
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 500 μg/mL in PBS.
  • Endotoxin
  • <0.1 EU/μg by the LAL method
  • Purity
  • >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • TSHR
  • Full Name
  • Thyroid stimulating hormone receptor
  • Introduction
  • The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • LGR3; CHNG1; hTSHR-I; thyrotropin receptor; TSH receptor; seven transmembrane helix receptor; thyrotropin receptor-I, hTSHR-I; TSHR; Thyroid stimulating hormone receptor

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