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NativeExtract™ Human CRHR2 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX286)

Datasheet
This product is recombinant Human CRHR2 protein in native nanodisc form. The synthetic compound we developed can solubilize the CRHR2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CRHR2
  • Protein Length
  • Full length
  • Molecular Weight
  • 47.7kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CRHR2
  • Full Name
  • Corticotropin releasing hormone receptor 2
  • Introduction
  • The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Alternative Names
  • CRF2; CRFR2; CRF-RB; HM-CRF; CRH receptor 2 variant B; CRH-R2; CRHR2; Corticotropin releasing hormone receptor 2

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