Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSolute carrier family 22 member 10 (SLC22A10), also known as the organic anion transporter 5 (OAT5), is a protein encoded by the SLC22A10 gene. Organic anion transporter 5 (OAT5), is characterized by an organic anion/dicarboxylic acid exchanger. This protein is localized on the edge film of the proximal tubule straight segment (S3). Oatmeal 5 has been reported to interact with many anionic drugs such as bumetanide, furosemide, penicillin G, and non-steroidal anti-inflammatory drugs. Under pathological conditions, the function of organic anion exchangers in kidney cells has not been fully elucidated.
| Basic Information of SLC22A10 | |
| Protein Name | Solute carrier family 22 member 10 |
| Gene Name | SLC22A10 |
| Aliases | Organic anion transporter 5 (OAT5) |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q63ZE4 |
| Transmembrane Times | 11 |
| Length (aa) | 541 |
| Sequence | MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGSGNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEKA |
SLC22A10 is expressed only in the kidney, and its urinary excretion is considered to be an early biomarker of kidney damage. The organic anion transporter (OAT) family consists of a group of more than 10 transmembrane proteins belonging to the SLC22 (solute carrier 22) subfamily of the major promoter superfamily (MFS). The SLC22 subfamily also includes organic cation transporters (OCTs) and organic carnitine (zwitterion) transporter (OCTNs). OAT family members are very similar in the subclass of the SLC22 transmitter and have many structural features with other MFS proteins. Modeling, mutagenesis, and other studies are consistent with the notion that these transmembrane proteins are composed of approximately 540-560 amino acids, consisting of 12 transmembrane domains.
Fig.1 The structure of SLC22A10 Protein.
This article suggests that organic anions of different pathophysiological importance can be absorbed/eliminated by using the outward gradient of citric acid produced by NaDC1.
The results that imply urinary excretion of SLC22A10 can be considered as a potential non-invasive biomarker for kidney damage associated with vascular calcification.
This article reveals that in system physiology, the effects of various forms of SLC22A10 appear to be quite complex, and their effects are discussed in the context of remote sensing and signal transmission.
These results suggest that urinary excretion of SLC22A10 may be an early indicator of renal insufficiency, which is useful for detecting small changes in kidney structural and functional integrity.
This review introduced organic anion transporters and its regulatory mechanisms.
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC22A10 antibody development services.
Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.
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