Recombinant technology is a valid method to reassemble two different originated DNA or protein molecules to produce new functional combinations. This effective gene editing tool has been worldwide used in genetic modifications and cell therapy field. Stem cells offer great hope to patients and scientists because of their potential to differentiate into any cell types to cure diseases, reverse injuries and offer highly targeted therapies to improve health outcomes. Creative Biolabs has employed a first-class recombinant stem cell platform, from which we provide the most diverse portfolio of products and services to generate innovative and effective cell therapy for customers all over the world.
Recombinant technology has been widely used in stem cell to direct stem cell differentiation into well-defined lineages, or to create new stem cell with more excellent properties in cell therapy.
The iPSCs technology is a great breakthrough in stem cell reprogramming field. iPSCs are derived from skin or blood cells that have been reprogrammed back into an embryonic-like pluripotent state that has the potential to differentiate into an unlimited source of any type of human cell needed for therapeutic purposes. The iPSCs cell therapy can avoid the post-transplant immune suppression because of the direct origination from the transplant recipient. Creative Biolabs has developed core scientific capabilities to maintain, characterize and bank the highest quality iPSCs.
Fig.1 Induced pluripotent stem cells (iPSCs) can differentiate into different cell types.
We can provide you the listed services:
We have successfully generated footprint-free (episomal) and retroviral iPSC lines from different tissues (fibroblasts, peripheral blood mononuclear cells, cord blood cells, nasal epithelial cells, urine-derived epithelial cells and CD34+ bone marrow) from both patients and healthy individuals. We are very proud that these cells lines are ideal in applications such as disease modeling, differentiation into cellular lineages of choice and drug toxicity/efficacy screening. Our dedicated scientists will provide ongoing support to help ease the adaptation of the cells into your experimental systems.
Fig.2 Work-flow of iPSCs in Creative Biolabs.
1) Retroviral Vectors: The specially optimized VSV-G retroviral vectors are used in this kit, from which you can generate pluripotent cell lines with high efficiency.
2) Episomal Vectors: Feeder-free, xeno-free, footprint-free reprogramming is a preferred method for both clinical applications and stem cell banking. Our proprietary episomal vectors are accompanied with detailed protocol make it easy to perform iPSC reprogramming.
Creative Biolabs provides cost-effective services to direct the differentiation of iPSCs to multiple cell types meeting your particular project needs. And our protocols are tailored for large-scale production.
Recombinant human stem cell factor (SCF) is an important hematopoietic factor, which acts on early hematopoietic stem cells, primitive hematopoietic progenitor cells and induces their the survival, proliferation and differentiation. It has been used in stem cell culture applications, including pre-clinical and clinical cell therapy studies. Creative Biolabs offers qualified and highly pure SCF products for our clients.
With years of operational experience, Creative Biolabs is able to provide the state-of-art services for stem cell recombination, which has great potential in stem cell therapy. It is exciting to offer our off-the-shelf product portfolio and outsourced services to help you get landmark development. If you are interested in learning more about Creative Biolabs' services, please contact us for more details.
For Research Use Only. Not For Clinical Use.
