Human LDLR Protein (Ala 22-Arg 788) [His] (VAng-1881Lsx)
Human LDLR protein, His tag, expressed in human 293 cells. (Uniprot ID: NP_000518.1)
Datasheet
Specifications
Source
HEK293 Cells.
Target
LDLR
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
LDLR (Low Density Lipoprotein Receptor) are involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
Alternative Names
LDLR, FH, FHC, LDLCQ2
Related Product
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