Marburg Virus Vaccines
Creative Biolabs is a world leader in the field of viral vaccine development. By consistently delivering the highest standards of quality, professionalism, and integrity, we want to become the partner of a choice for your requirements. With our extensive experience and advanced platform, we are therefore confident in offering the best vaccine development services for Marburg virus disease. We guarantee the finest results for our customers all over the world.
Marburg virus disease (MVD) is caused by a hemorrhagic fever virus of the Filoviridae family. It is a severe and highly fatal disease that produces symptoms of fever, chills, headaches, and muscle aches early in the disease; symptoms worsen and may lead to hemorrhagic fever and death. MVD is endemic in Africa with case fatality rates of up to 90% and can be transmitted from person to person by exposure to blood and other bodily secretions. Marburg viruses are filamentous particles that may appear in the shape of a shepherd's crook or in the shape of a "U" or a "6", and they may be coiled, toroid, or branched. Actual treatment of the virus after infection is not possible but early, professional treatment like vaccination considerably an effective administration.
Many candidate vaccines have been developed, of which, the most promising ones are DNA vaccines or recombinant viral vectors vaccine or virus-like particle (VLP)-based vaccine, all of these candidates could protect nonhuman primates from marburgvirus-induced disease.
DNA Vaccine
We built a multiagent DNA vaccine for highly pathogenic organisms that are known as biowarfare agents, Bacillus anthracis, Ebola, Marburg, and Venezuelan equine encephalitis virus, can elicit protective immunity in relevant animal models. In addition, test was designed to compare the effect of immune response in this vaccine and a combination of all four vaccines, result is shown to be equal for both types. Therefore, the multiagent DNA vaccine has the potential of these four agents and point to a possible method of rapid development of multiagent vaccines for preventing naturally occurring or deliberately introduced diseases.
Recombinant Viral Vectors Vaccine
An RNA replicon which was based upon Venezuelan equine encephalitis (VEE) virus was used as a vaccine vector. In the design of the vaccine, the VEE structural genes were replaced by genes for Marburg virus glycoprotein, nucleoprotein, VP40, VP35, VP30, or VP24. Immunization with either killed Marburg virus or a glycoprotein subunit could prevent lethal infection in guinea pigs. As a more definitive test of vaccine efficacy, nonhuman primates were inoculated with VEE replicons expressing Marburg virus glycoprotein and/or nucleoprotein. The experimental group vaccinated with replicons that expressed glycoprotein or nucleoprotein was completely protected from MVD. It gives a choice to develop the vaccines against MVD.
Virus-like Particle (VLP)-based Vaccine
Virus-like particle (VLP)-based vaccines obtain a lot of focus due to the advantage of being morphologically and antigenically similar to the live virus from which they are derived. In the development of Marburg virus vaccine, the glycoprotein and VP40 matrix protein from Lake Victoria marburgvirus (MARV) were spontaneously expressed to product of VLPs in mammalian cells. Animals like Guinea pigs or macaques were vaccinated with Marburg virus VLPs (mVLPs), both types of animals develop humoral and T-cell responses and were completely protected from a lethal homologous MARV challenge, showed the mVLPs could broadly protect against MVD. Thus, mVLPs can be a suitable candidate with the broad immunity and efficient protection against Marburg virus.
Creative Biolabs is a highly proactive, robust, and diversified company with a strong, scientifically-proven background of viral vaccine development. We have experts who are able to help you with the vaccine development against Marburg virus disease. If you are interested in our services, please contact us for more details.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
