Polyarginine-Mediated Protein/Peptide Delivery Platform
Polyarginine-mediated protein delivery to dendritic cells more efficiently presents antigens to MHC class I and class II and elicits superior anti-tumor immunity. Equipped with a team of professional scientists, Creative Biolabs is capable of providing specialized support for your drug delivery using our polyarginine-mediated delivery platform, triggering robust cellular and antibody immune responses. We can accommodate the specific attributes of your project and provide flexible and integrated solutions.
Polyarginine
Polyarginine-mediated protein delivery to dendritic cells more efficiently presents antigens to MHC class I and class II and elicits superior anti-tumor immunity. As one of the positively charged polymers, polyarginine is a biodegradable polyamino acid which belongs to the cell-penetrating peptide (CPP) family. It has the potential to become a promising biomaterial for the design of vaccine delivery systems. The cell penetrating properties of arginine-rich polyamino acids are attributed to the presence of purine functional groups, which are known to specifically interact with cell surface domains prior to their internalization. Polyarginine has been shown to interact with tight junction proteins, occludin and ZO-1 to promote paracellular transport of hydrophilic drugs, which are believed to be the basis for the reported Polyarginine -improving peptides across the Caco-2 intestinal epithelial model and the ability to transport the nasal and ocular mucosa. The polyarginine-mediated delivery system shows its ability to deliver the anticancer drug docetaxel intracellularly. They are quite stable and have the ability to pass through the epithelial barrier.
Fig.1 Illustration of the structure of PArg (poly-L-arginine) nanocapsules. (Lollo G. 2017)
Polyarginine-Mediated Protein/Peptide Delivery Platform
Dendritic cells (DC) are the most potent antigen (Ag) presenting cells in the immune system. The development of anti-tumor immunity requires the strategy that is capable of stimulating CD8+ cytotoxic T lymphocytes (CTLs) to efficiently deliver Ag to major histocompatibility complex (MHC) class I molecules. It may be crucial to simultaneously induce strong Ag-specific CD8+ and CD4+ T cell responses by presenting tumor Ags containing MHC class I and class II binding peptide epitopes. Homopolymers or peptides containing a high percentage of cationic amino acids have been shown to have a unique ability to cross the plasma membrane of the cell and have therefore been used to promote uptake of various biopolymers and small molecules. Polyarginine-mediated protein delivery to dendritic cells more efficiently presents antigens to MHC class I and class II and elicits superior anti-tumor immunity.
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Reference
- Lollo G, et al. Polyarginine Nanocapsules as a Potential Oral Peptide Delivery Carrier. J Pharm Sci. 2017, 106(2):611-618.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
