Recombinant 4-1BB Protein (aa 1-186) [Fc] (VAng-2779Lsx)
Recombinant 4-1BB Protein, fused to the Fc portion of human IgG1, was expressed in HEK 293 cells. (Uniprot ID: Q07011)
Datasheet
Specifications
Source
HEK 293 Cells
Target
4-1BB
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
4-1BB is a member of the tumor necrosis factor (TNF) receptor family. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule. It can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, 4-1BB expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of 4-1BB is its costimulatory activity for activated T cells. Crosslinking of 4-1BB enhances T cell proliferation, IL-2 secretion, survival and cytolytic activity.
Alternative Names
CD137; ILA; TNFRSF9; 4-1BB; CDw137
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
