Bulk Antibody Production Services

Background Our Services Deliverables Features

Over the past years, Creative Biolabs has built up an efficient, cost-effective system of manufacturing monoclonal antibodies (mAbs) on a contract basis. There are two types of custom mAb production, in vivo (typically in BALB/c mice), and in vitro (using bioreactors). The price can be based on any one of the following:

Per volume ascites
Per milligram of antibody in ascites or supernatant media
Per milligram of purified antibody

Background

The demand for monoclonal antibodies (mAbs) for research, therapeutic, or diagnostic uses has been continuously rising during the past decades. The need for bulk production of effective, safe, and affordable mAbs at a large scale has advanced the development of strategies. Commercially, mAbs are produced by in vivo and in vitro technology. The former relies on experimental animals, while the latter involves small-scale suspension cell culture production or high cell density bioreactor systems for mAb production in higher quantities. Selecting and designing the appropriate production scheme according to your specific needs facilitates your project success and budget savings.

Fig.1 Representation of a novel hollow fiber bioreactor for mAb production.¹

Custom In Vitro & In Vivo Bulk Antibody Production Services

Bulk mAb production is a multi-step process. The first step is hybridoma development. Creative Biolabs offers hybridoma development services if there is no existing hybridoma available to the customer. Alternatively, an existing hybridoma could be shipped to Creative Biolabs via appropriate shipping procedures. Careful shipment ensures the safety and viability of the hybridoma cell.

If the hybridoma is cultured in the serum-containing medium, Hybridoma Suspension Domestication Service is available for customers and thus hybridoma could be cultured in a serum-free medium which provides great convenience for subsequent antibody purification. Creative Biolabs also offers Hybridoma Cell Line Optimization Services for maximum mAb production. Each service mentioned above can be provided separately or included in a customized project. Our antibody bulk production services include but are not limited to:

Final Deliverables

Ascites, purified mAb, or concentrated supernatant to requested scale
Working cell bank for scale-up cell line
Project report with ELISA, SDS-PAGE, WB, HPLC, and SEC performance data

Why Creative Biolabs?

Your scientific partner provides guided antibody solutions
Over 15 years of experience in antibody-focused R&D and custom hybridoma development
Generating the desired immune response for your most challenging antigens

Creative Biolabs has confidence in speeding your bulk antibody production and delivering the final products with fast turnaround time and high quality. For more detailed information, please feel free to contact us.

Reference

Jyothilekshmi, I., and N. S. Jayaprakash. "Trends in monoclonal antibody production using various bioreactor systems." Journal of Microbiology and Biotechnology 31.3 (2021): 349.
Distributed under Open Access license CC BY 4.0, without modification.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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