Exosomal Peptidomics Services, offering a cutting-edge biotechnological platform, focuses on the in-depth study of the rich peptide and low molecular weight protein content within exosomes. These tiny yet powerful molecular assemblies not only reflect the health status of cells but also reveal subtle changes during physiological and pathological processes. Creative Biolabs is dedicated to uncovering the secrets behind these peptides, thereby providing our clients with critical information regarding disease mechanisms, diagnostic markers, therapeutic targets, and drug development.

Fig.1 Comparison of strategies to isolate the plasma peptidome.^1,2

Introduction to Exosomal Peptidomics

Our service workflow encompasses a full set of steps from precise sample preparation, meticulous peptide extraction, to advanced mass spectrometry analysis and in-depth data interpretation. We are not only capable of identifying and quantifying peptides present in samples but more importantly, we can explore the biological functions and pathological significance behind these peptides. By utilizing efficient, high-throughput, and highly specific techniques, we ensure the sensitivity and accuracy of the analysis process while minimizing potential damage during sample handling.

Exosomal Peptidomics Application Directions

• Comprehensive analysis of exosomal peptides: We perform comprehensive analyses of exosomal peptides under specific physiological or pathological conditions, revealing their functions and mechanisms of action, providing deep insights into cell communication and disease mechanisms.
• Exploration of disease biomarkers: By identifying specific peptides carried by exosomes, we pave a new path to early diagnosis and therapeutic efficacy assessment.
• Discovery of functional peptides and new drug precursors: We are committed to exploring the biological activity of peptides within exosomes, developing new drug candidate molecules, and providing a solid foundation for the discovery and development of innovative drugs.
• Research on unknown enzymatic reactions: By analyzing changes in exosomal peptides, we reveal unknown enzymatic reactions and signaling pathways, offering new insights for biological research.

Sample Requirements

Advantages of Creative Biolabs Services

• Efficiency and high throughput: Our services can efficiently and quickly process and analyze peptides in multiple samples.
• High specificity: We employ antibody-independent techniques, thereby avoiding cross-reactivity issues and enhancing analytical accuracy.
• Minimal destructiveness: We use gentle sample handling methods to ensure the structural and functional integrity of peptides.
• High sensitivity: We utilize the most advanced high-sensitivity, high-resolution mass spectrometry platforms, ensuring extremely high detection accuracy and reliability.

By combining cutting-edge peptidomics technology with forefront research in exosome biology, Creative Biolabs offers powerful exosomal peptidomics services to our clients. This service not only opens new avenues for a deep understanding of biological processes, unveiling disease mechanisms, developing new drugs, and realizing precision medicine but also is expected to play an increasingly important role in the fields of life sciences and health care as technology advances and application areas continue to expand. Please contact us to explore the limitless possibilities of exosome peptidomics analysis together.

References

1. Parker, BL.; et al. Multiplexed temporal quantification of the exercise-regulated plasma peptidome. Molecular & Cellular Proteomics. 2017, 16(12):2055-2068.
2. under Open Access license CC BY 4.0, without modification.

• Phosphorylated Exosomal Proteomic Detection
• Label-free Exosomal Proteomic Detection
• Labeled Exosomal Proteomic Detection
• Four-Dimensional Exosomal Proteomic Detection
• FMRM/PRM Targeted Exosomal Proteomic Quantitative
• Ultra-sensitive Targeted Exosomal Proteomic Detection
• Glycosylated Exosome Detection