Mulberry Bark-derived Exosome Research and Application
Mulberry bark, as a natural resource, has long been widely used in various fields. However, the potential of exosomes derived from mulberry bark remains to be explored. Creative Biolabs offers an introduction to mulberry bark-derived exosomes to help customers better understand and harness this important biological resource.
Benefits of Mulberry Bark
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Respiratory Relief: Mulberry bark is beneficial for the respiratory system, alleviating coughing, wheezing, and clearing phlegm. Research suggests it helps regulate the immune system, clear harmful oxidative substances, enhance virus resistance, and alleviate discomfort caused by asthma and respiratory infections.
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Kidney Protection: Mulberry bark significantly increases urine production, aiding in the elimination of excess uric acid to protect kidney health. It also shows positive effects on kidney function impairment and edema symptoms.
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Cardiovascular Protection: Mulberry bark contains flavonoids that can improve blood sugar, total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels in diabetes patients, contributing to cardiovascular health. Additionally, it may protect the cardiovascular system by enhancing antioxidant enzyme function.
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Pain Relief and Anti-Inflammation: Flavonoid compounds in mulberry bark have potential roles in inhibiting inflammatory responses and providing pain relief by reducing the release of inflammatory factors.
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Anti-Cancer: Research indicates that mulberry bark has some anti-cancer potential, inhibiting the proliferation and spread of various cancer cells, including prostate, lung, and colon cancer. This suggests its potential application in cancer treatment.
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Liver Protection: Mulberry bark has a protective effect on the liver, reducing acute liver damage and non-alcoholic fatty liver disease. It may achieve this by regulating the expression of specific genes and inhibiting oxidative stress.
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Antiviral: Early studies suggest that mulberry bark may have inhibitory effects against HIV and other viral infections, reducing viral replication and transmission.
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Antioxidant and Whitening: Active ingredients in mulberry bark possess antioxidant abilities, clearing free radicals to protect cells from oxidative stress damage. Additionally, it can reduce melanin production, potentially offering skin whitening and anti-aging benefits.
Research on Mulberry Bark-derived Exosomes
Exosomes are small vesicles released by cells that can carry various bioactive molecules for intercellular signaling and material exchange. Therefore, mulberry bark-derived exosomes may carry bioactive components related to mulberry bark's benefits, delivering these beneficial substances in the human body and exerting similar pharmacological effects. Previous research has revealed one such effect of mulberry bark-derived exosomes.
Title: Exosome-like nanoparticles from mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway.
Research Methods:
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Extraction of exosomes from mulberry bark using ultracentrifugation and sucrose density gradient centrifugation.
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Treatment of colitis mice with mulberry bark-derived exosomes to study their effects on mouse weight, intestinal tissues, and bacterial communities.
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Treatment of mouse intestinal epithelial cells with mulberry bark-derived exosomes to investigate their impact on the AhR signaling pathway, COPS8 expression, and antimicrobial peptide secretion.
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Validation of the roles of AhR signaling pathway, COPS8, and HSPA8 in the anti-inflammatory effects of mulberry bark-derived exosomes using gene knockout mice or pharmacological inhibitors.
Research Results:
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Mulberry bark-derived exosomes effectively prevent colitis in mice.
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They alleviate colitis by activating the AhR/COPS8 pathway in intestinal epithelial cells and synthesizing various antimicrobial peptides.
Conclusion: Exosomes from mulberry bark can prevent colitis by activating the AhR-COPS8 signaling pathway. Therefore, mulberry bark-derived exosomes may have the potential as novel drugs for preventing and treating inflammatory bowel diseases.
Plant Exosome Development Platform at Creative Biolabs
Creative Biolabs provides a platform for plant exosome development to support research and applications of exosomes derived from plants. Our expertise and technology can accelerate research and development of plant-derived exosomes, potentially leading to more innovative discoveries. If you are interested in mulberry bark-derived exosomes or other plant-derived exosomes, contacting us may help further explore the potential of this field and contribute to future treatment methods and drug development.
Plant-Derived Exosome Isolation
Plant-Derived Exosome Identification
High-Throughput Screening Analysis (Proteins, RNA, Lipids and Metabolites)
Large-Scale Production of Plant-Derived Exosomes
Reference
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Sriwastva, MK.; Deng, ZB.; et al. Exosome-like nanoparticles from mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway. EMBO Reports. 2022, 23(3):e53365.
For Research Use Only. Cannot be used by patients.
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