GABRA3 Membrane Protein Introduction

Introduction of GABRA3

Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3), also known as GABA-A receptor subunit alpha 3, is a protein that in humans is encoded by the GABRA3 gene. It is a subunit of the gamma-aminobutyric acid (GABA) type A receptor family of heteromeric pentameric ligand-gated ion channels.

Basic Information of GABRA3
Protein Name	Gamma-aminobutyric acid receptor subunit alpha-3
Gene Name	GABRA3
Aliases	GABA(A) receptor subunit alpha-3
Organism	Homo sapiens (Human)
UniProt ID	P34903
Transmembrane Times	4
Length (aa)	492
Sequence	MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ

Function of GABRA3 Membrane Protein

Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the mammalian brain that specifically interacts with two major classes of receptors: GABA-A receptor (α1–6, β1–3, γ1–3, δ, ε, θ, π, ρ1–3) and GABA-B receptor (GABBR1 and GABBR2). As a member of the GABA-A receptor family, GABARA3 is expressed much more strongly in normal human tissues than in other adult organs with the highest GABARA3 expression being in the fetal brain. The GABARA3 expression is also pronounced in the cortex and thalamus at embryonic and early postnatal stages in rat, indicating its role in the development of cortical plate. What’s more, studies have shown that high expression of GABRA3 is associated with disease stage, lymphatic metastasis status and poor patient survival, which including but not limited to lung adenocarcinoma and breast cancer.

Fig.1 Modulation of extrasynaptic GABAA receptors. (Connelly, 2013)

Application GABRA3 of Membrane Protein in Literature

Long M., et al. miR-92b-3p acts as a tumor suppressor by targeting Gabra3 in pancreatic cancer. Molecular cancer. 2017, 16(1):167. PubMed ID: 29078789

This article suggests that miR-92b-3p may act as a tumor suppressor by targeting Gabra3-associated oncogenic pathways which provide novel insight into future treatments for pancreatic cancer patients.
Kim M., et al. Expression levels of GABA-A receptor subunit alpha 3, Gabra3 and lipoprotein lipase, Lpl are associated with the susceptibility to acetaminophen-induced hepatotoxicity. Biomolecules & Therapeutics. 2017, 25(2):112. PubMed ID: 27530116

This article reports that the expressions of Gabra3 and Lpl are significantly correlated with the severity of liver injury (p<0.05) demonstrating that these genes may be linked to the susceptibility to APAP-induced hepatotoxicity.
Liu L, et.al. GABRA3 promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases. Oncotarget. 2016 May 31; 7(22):32341. PubMed ID: 27081042

This article suggests that high GABRA3 protein expression in lung adenocarcinoma is correlated with disease stage, lymphatic metastasis status and poor patient survival which indicates that GABRA3 could promote lymph node metastasis and thus be an effective therapeutic target for anticancer treatment.
Gumireddy K., et al. The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis. Nature communications. 2016, 7:10715. PubMed ID: 26869349

This article suggests that Gabra3 could activate the AKT pathway to promote breast cancer cell migration, invasion, and metastasis. It demonstrates that mRNA-edited Gabra3 plays a significant role in breast cancer metastasis.
Miller B.H., et al. Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice. Mammalian Genome. 2010, 21(5-6):247-57. PubMed ID: 20512339

This article suggests that GABRA3 has the ability to regulate a behavioral endophenotype of depression and it can be used as a viable new target for the study and treatment of human depression.

GABRA3 Preparation Options

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Reference

Connelly, et al. (2013). Metabotropic regulation of extrasynaptic GABAA receptors. Frontiers in neural circuits. 7, 171.

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