Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsIntroduction of GABRR3
The Gamma-aminobutyric acid receptor subunit rho-3(GABRR3), which in humans is encoded by the GABRR3 gene, is also known as a GABAA-ρ receptor. GABRR3 is a member of the rho subunit family, which is also named as GABA(C) receptor. GABA receptors are ligand-gated chloride channels. GABA is a major inhibitory neurotransmitter in the mammalian brain. GABRR3 may play an important role in retinal neurotransmission.
| Basic Information of GABRR3 | |
| Protein Name | Gamma-aminobutyric acid receptor subunit rho-3 |
| Gene Name | GABRR3 |
| Aliases | GABA(A) receptor subunit rho-3, GABA(C) receptor |
| Organism | Homo sapiens (Human) |
| UniProt ID | A8MPY1 |
| Transmembrane Times | 4 |
| Length (aa) | 467 |
| Sequence | MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQKYEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV |
Function of GABRR3 Membrane Protein
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain. GABAergic receptor abnormalities have been found playing an important role in several major psychiatric disorders, including schizophrenia, mood disorders, and autism. The γ-aminobutyric acid type C (GABAC) receptors, also known as γ-aminobutyric acid type A rho (GABAA-ρ) receptors are ligand-gated ion channel receptors that activated by GABA, the most inhibitory neurotransmitter substance in the vertebrate CNS (central nervous system). GABAC Receptors are consist of three subunits (ρ1-3) that originally belonged to the GABAA Receptor subtype has been associated to memory, learning, visual processing, regulation of sleep–waking rhythms, pain perception, regulation of hormones and neuroendocrine gastrointestinal secretion. These receptors are localized in the retina, thalamus, hippocampus, pituitary and gastro intestinal tract.
Fig.1 The structure of GABAC receptors. (Strauss, 2011)
Application of GABRR3 Membrane Protein in Literature
This article provides new information supporting the role of missense GABA-A receptor polymorphisms in reaction time, motor time and effects of low ethanol doses in vivo.
The article suggests that changes in GABAergic function could be an important factor in both early and later stages of AD pathogenesis.
The article reveals that the increased GABA shunt could be the supply of intermediates to feed the tricarboxylic acid cycle of respiration metabolism during long-term heat stress, thereby maintaining metabolic homeostasis.
The research suggests that GABRR3rs832032 polymorphism is associated with the risk for RLS, and there is a modifier effect of GABRA4 rs2229940 on the age of onset of RLS.
The results suggest that GABRR genes seem to be not associated with the risk of migraine in Caucasian Spanish people.
GABRR3 Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GABRR3 antibody development services.
Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.
Reference
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
