GTOnco™ DC Migration Assay
Dendritic cells (DCs) are central players of the immune system and the migration of DCs into secondary lymphoid organs and tissues plays a crucial role in the initiation of innate and adaptive immunity. Immature DCs with strong migration ability are activated by the hapten-protein complex and differentiated from antigen-capture and processing cells into potent immunostimulatory DCs to present antigen effectively to effector T-cells. Most DC‑driven responses require their migration to a certain target destination to promote immunity. Based on the outstanding expertise and rich experience, Creative Biolabs has the capability to provide high-quality DCs migration assay service to help our clients understand the pathogenesis of a range of diseases and accelerate their development of gene therapy-based I-O products.
Figure 1. Trafficking of intestinal antigen-presenting cells. (Worbs, 2016)
Migration is truly at the heart of DCs biology and most of the migration events are controlled by specific molecular guidance cues, including chemokine-chemokine receptor system (e.g. CCR7, CCL19 and CCL21) and some factors interacting with the DCs cytoskeleton. Taking advantage of the GTOnco™ platform, Creative Biolabs provides customized, standardized, reliable and high-quality DCs migration assay services for clients across the world.
Our one-stop services cover all aspects of DC migration study, including maturation and mobilization of tissue-resident DCs, intranodal migration and positioning of DCs and the migration in the skin, intestines, lung, central nervous system (CNS), atherosclerosis and inflammatory diseases, etc. In addition, the research of DCs subset or surface markers and the routes, cues and molecular basis of DCs migration are also available at GTOnco™ platform. We will design assay protocols for customers and select the most appropriate method to advance your gene therapy-based I-O drugs development.
At Creative Biolabs, our scientists will professionally perform best-fit DCs migration assay to assist our clients to understand the anti-tumor mechanism and support the development of their I-O products. We are pleased to share our precious experience in immunotherapy with our clients. Please contact us to learn more information. Our team will get back to you as soon as possible.
Reference
- Worbs, T.; et al. (2016). Dendritic cell migration in health and disease. Nature Reviews Immunology. 17(1), pp.30-48.
