GTOnco™ Responsive T Cell Trafficking Assay
Generally, Naïve T lymphocytes are programmed to recirculate predominantly in secondary lymphoid tissues and these primed T cells exert targeted effector responses by identifying specific sites of antigen located in non-lymphoid tissue. Following priming, the trafficking properties of T cells are changed and these activated and effector T cells acquire the ability to effectively and specifically home to other organs, which is mediated by tissue-selective adhesion and chemokine receptors. Based on the outstanding expertise and rich experience, Creative Biolabs provides the best-fit in vitro T cell trafficking assays to visualize organ-specific homing of T cells. GTOnco™ platform is committed to helping our clients evaluate gene therapy-based I-O drug candidates with possible properties that can affect the migration of immune cells, and in turn influence their anti-tumor ability.
Figure 1. T-cells migrate into lymphoid and non-lymphoid tissues. (Fu, 2013)
The study of T-cell migration in cancer research is of particular interest in the gene therapy-based I-O drug development. The stimulation of the recruitment of immune cells and their infiltration into the tumor masses are primordial for effective anti-tumor immune responses to counter disease progression. GTOnco™ platform offers valuable in vitro cell-based analysis system to evaluate the I-O drugs' effects on the migration of immune or cancer cells. Based on the advanced technology, our system enables automated, real-time analysis of immune cell migration profiles.
Features of Our Responsive T Cell Trafficking Assay at GTOnco™ Platform
- Real-time monitor and quantify directional migration of immune cells.
- Various types of immune cells migration assays are available, including effector T cells, Th17, regulatory T cells (Treg), macrophages, neutrophils and dendritic cells.
- Rich experience and advanced cell analysis system to support your development of novel therapeutic strategies.
Leveraging our industry expertise, Creative Biolabs is constantly enhancing our in vitro GTOnco™ platform and provides responsive T cell trafficking assay to serve your gene therapy-based I-O drugs development. Contact us today for a proposal to support all of your immuno-oncology research needs.
Reference
- Marelli-Berg, F. (2013). T lymphocyte trafficking: molecules and mechanisms. Frontiers in Bioscience. 18(2), p.422.
