Melanocytes-targeting Adenovirus Vector Construction Service
Creative Biolabs has developed a fail-proof adenovirus vector construction platform for our clients all over the world. We have integrated high-quality viral vector services which are based in America and span the entire development chain from discovery to commercialization. Our company offers the best guarantee in vector construction and has successfully developed a series of melanocytes-targeting adenovirus vector for various disease therapy.
Introduction of Melanocytes in Gene Therapy
Melanocytes are a group of cells that play a critical role in preventing the mutations caused by ultraviolet radiation. Previous studies have demonstrated that the loss-of-function of melanocytes is related to the occurrence and development of various diseases, including melanoma, albinism, pigmentation-associated disorders. For the disease treatment, studies focused on studying of melanocyte functions have been conducted by many organizations and companies. The results indicate that gene therapy should be a perfect method for treating melanocytes-based diseases, for instance, gene-targeted drugs have become available in a number of clinical trials. Meanwhile, vectors that can efficiently transduce melanocytes have aroused much attention.
Among them, adenovirus vectors (Ads) have been regarded as one of the most effective viral vectors in gene transfer because of the stability in vivo and high transfer efficiency in vitro. Furthermore, pilot studies have revealed that Ads have a large scale of native tropism, and have the ability of specifically targeting on the disease-related melanocytes. As a consequence, melanocytes-targeting adenovirus vector may provide a unique therapeutic intervention to selectively destroy or restore the function of melanocytes in patients.
Figure 1. Melanocytes-targeting Adenovirus Vector Service.
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Recent researchers have shown that adenovirus vectors can provide safe and efficient gene transduction in melanocytes with a rate of more than 90%. To date, adenovirus vectors have been widely used for in vitro studies of melanocyte functions and gene therapy in melanocytes-associated diseases, such as melanoma. As a professional expert in viral vector construction, Creative Biolabs provides a full range of services in adenovirus vector manufacturing for gene delivery and gene therapy applications, ranging from adenovirus vector design, packaging, animal trials to GMP production. In recent studies, we have developed a wide variety of melanocytes-targeting adenovirus vectors for our worldwide customers. For instance, a tumor necrosis factor α-based gene therapy has been developed using adenovirus vectors targeting MART-1 or gp100. The safety, efficacy and immunogenicity have been evaluated by our labs. Additionally, the coxsackievirus-adenovirus receptor (CAR) has also been modified by adenovirus vectors, and an Arg-Gly-Asp (RGD)-containing peptide has been inserted into the adenovirus type 5 (Ad5) fiber proteins to improve the transduction rate in gene therapy for CAR-deficient melanomas.
Creative Biolabs offers a broad range of custom viral vector services at a reasonable cost and with quick turnaround time. Our highly experienced scientists are ready to tackle difficult viral vector projects, such as lentiviral vector and adenovirus vector, to meet any requirement. Please contact us with your project details and our team will get in touch as soon as possible with an estimated price.
