GPR152 Membrane Protein Introduction

Introduction of GPR152

GPR152 belongs to the G-protein-coupled receptor (GPCR) family which is one of the largest families of proteins in the human genome and participates in a diversity of important physiological functions and is a target for many modern drugs. The human GPR152 was discovered in the nr database as hGPCR38 and as anonymous heat-stable fragment RP8-9Q (199 residues). GPR152 is encoded by the GPR152 gene, which is located at 11q13.2. And the mass of GPR152 is 50,962 Da.

Basic Information of GPR152
Protein Name	Probable G-protein coupled receptor 152
Gene Name	GPR152
Aliases	G-protein coupled receptor PGR5
Organism	Homo sapiens (Human)
UniProt ID	Q8TDT2
Transmembrane Times	7
Length (aa)	470
Sequence	MDTTMEADLGATGHRPRTELDDEDSYPQGGWDTVFLVALLLLGLPANGLMAWLAGSQARHGAGTRLALLLLSLALSDFLFLAAAAFQILEIRHGGHWPLGTAACRFYYFLWGVSYSSGLFLLAALSLDRCLLALCPHWYPGHRPVRLPLWVCAGVWVLATLFSVPWLVFPEAAVWWYDLVICLDFWDSEELSLRMLEVLGGFLPFLLLLVCHVLTQATACRTCHRQQQPAACRGFARVARTILSAYVVLRLPYQLAQLLYLAFLWDVYSGYLLWEALVYSDYLILLNSCLSPFLCLMASADLRTLLRSVLSSFAAALCEERPGSFTPTEPQTQLDSEGPTLPEPMAEAQSQMDPVAQPQVNPTLQPRSDPTAQPQLNPTAQPQSDPTAQPQLNLMAQPQSDSVAQPQADTNVQTPAPAASSVPSPCDEASPTPSSHPTPGALEDPATPPASEGESPSSTPPEAAPGAGPT

Function of GPR152 Membrane Protein

GPR152 is an orphan receptor belongs to the rhodopsin γ-receptors. In terms of structure, the GPR152 C-terminus is relatively long and the rodents have two additional sequence stretches in their C-termini. At the same time, the entire C-termini of the rodent receptors is about 220 residues long. The activity of GPR152 is mediated by G proteins, resulting in the activation of adenylyl cyclase and elevating intracellular cAMP. It has been reported that a 26-kb locus on 11q13.1 is associated with diffuse-type gastric cancer, and rs1790761 in GPR152 showed significant allelic associations with susceptibility to the disease. Beyond that, GPR152 is 29% and 27% identical to CRTH2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) and the FPRL1 (formyl-peptide-receptor-like 1), respectively. And these two receptors display only 35% identity between themselves but have both been shown to be involved in inflammatory reactions. Therefore, it is possible that GPR152 has a similar function as these receptors have.

Fig.1 Mammalian reporter assays for transcription factors downstream of each of the major GPCRs (Ngo, 2016).

Application of GPR152 Membrane Protein in Literature

Ju H., et al. A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. Neoplasia. 2009, 11(12):1340-1347. PubMed ID: 20019842

This article reports that a 26-kb locus on 11q13.1 is associated with diffuse-type gastric cancer, and rs1790761 in GPR152 showed significant allelic associations with susceptibility to the disease.
Gloriam D. and Schioth H.R. Nine new human Rhodopsin family G-protein coupled receptors: Identification, sequence characterisation and evolutionary relationship. BBA - General Subjects. 2005, 1722(3):235-246. PubMed ID: 15777626

This article reports nine new human Rhodopsin family GPCRs, and their Identification, sequence characterization and evolutionary relationship. One of them is GPR152.
Regard J.B., et al. Anatomical profiling of G protein-coupled receptor expression. Cell. 2008, 135(3):561-571. PubMed ID: 18984166

This article introduces anatomical profiling of G protein-coupled receptor expression. GPR152 is a research object and some characterization of it has been revealed in the passage.
Shi Z.Z., et al. Identification of putative target genes for amplification within 11q13.2 and 3q27.1 in esophageal squamous cell carcinoma. Clinical & Translational Oncology. 2014, 16(7):606-615. PubMed ID: 24203761

Authors in this article identified putative target genes for amplification within 11q13.2 and 3q27.1 in esophageal squamous cell, and GPR152 is located at 11q13.2, the article is also relative to GPR152.

GPR152 Preparation Options

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Reference

Ngo T, et al. (2016). Identifying ligands at orphan gpcrs: current status using structure‐based approaches. British Journal of Pharmacology. 173(20), 2934-2951.

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