As PC is a major component of cell membranes, DOPC liposomes provide a model system for studying bilayer formation and properties.
By comparing them with cholesterol-containing liposomes, researchers can study the effects of cholesterol on membrane properties.
It is advised to take extreme care in not contaminating the vial, and it is recommended to handle the vial under a sterile hood.
Ice crystals that form during freezing will rupture the lipid membrane of the liposomes, changing their size.
Dependence of the ratio h/Rc on the Req for the DOPC liposomes.
This study measured the dielectric properties and lamellarity of single liposomes using scanning dielectric microcopy (SDM). The researchers characterized the size and shape of DOPC liposomes using the equivalent spherical radius (Req) and the h/Rc. The results demonstrate that the ratio h/Rc ratio of DOPC liposomes is related to Req, indicating a correlation between lamellarity and size. Using DOPC liposomes as a model system, this paper reveals the relationship between dielectric properties and lamellarity, providing a foundation for understanding the functions of biological membranes.
Di Muzio, Martina, et al. "Dielectric properties and lamellarity of single liposomes measured by in-liquid scanning dielectric microscopy." Journal of Nanobiotechnology 19.1 (2021): 167.
Distributed under Open Access license CC BY 4.0, without modification.
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