The study detailed in the provided document explores the enhancement of liposome integrity and antioxidant activity by incorporating squalene (SQ) into mixed soy lecithin-based liposomes. The research examines the effects of different membrane compositions and concentrations on liposome stability, especially under UV light exposure. Liposomes were prepared using a mixture of SQ, cholesterol (CH), and Tween80 (TW80) with optimized formulations identified. The optimal liposome formulation contained 5% (w/w) mixed soy lecithin (ML), 0.5% (w/w) SQ, 0.3% (w/w) CH, and 0.75% (w/w) TW80. This formulation exhibited favorable physicochemical properties, including a low particle size of 158.31 ± 2.96 nm, and maintained integrity with a 15.09% ± 3.76% increase in particle size and a 35.69% ± 0.72% decrease in trolox equivalent antioxidant capacity (%TEAC) under UV treatment for 6 hours. The inclusion of SQ significantly improved liposome stability and antioxidant activity. SQ's presence in the liposome membrane increased acyl chain dynamics and decreased viscosity, limiting long-term stability issues. The study highlights the potential of SQ in enhancing liposome formulations, making them more stable and effective for applications in food and nutraceutical delivery systems.
Toopkanloo, S. P., Tan, T. B., et al. Improving vesicular integrity and antioxidant activity of novel mixed soy lecithin-based liposomes containing squalene and their stability against UV light. Molecules. 2020, 25(24): 5873. Under Open Access license CC BY 4.0, selected from part of Figure 2.
For Research Use Only. Not For Clinical Use 
