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Magic™ Antibody Discovery - Human Bcl-x / BCL2L1 (2-212) Membrane Protein, Partial, GST- tag (CAT#: MP1047F)

Datasheet
This membrane protein is Human Bcl-x / BCL2L1 (2-212). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Bcl-x / BCL2L1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 50.6 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE).
  • Sequence
  • AA Ser 2 - Arg 212 (Accession # AAH19307).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • E.coli
  • Tag
  • GST tag at the N-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >92% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 100 mM NaCl, pH7.5 with 10 mM GSH. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Bcl-x / BCL2L1
  • Full Name
  • BCL2 like 1
  • Introduction
  • The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
  • Alternative Names
  • BCLX; BCL2L; Bcl-X; PPP1R52; BCL-XL/S; bcl-2-like protein 1; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52

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