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Magic™ Antibody Discovery - Human PDGF-BB (82-190) Membrane Protein, Partial (CAT#: MP0799F)

Datasheet
This membrane protein is Human PDGF-BB (44-750). It has been tested in SDS-PAGE, ELISA, Cell based assay. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PDGF-BB
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 12.4 kDa. The reducing (R) protein migrates as a 14 kDa polypeptide and the non-reducing (NR) disulfide-linked homodimer migrates as a 27-32 kDa protein.
  • Sequence
  • AA Ser 82 - Thr 190 (Accession # P01127-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, Cell based assay
  • Expression Systems
  • E.coli
  • Tag
  • No tag
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 0.085% TFA in 30% ACN. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • PDGF-BB
  • Full Name
  • platelet derived growth factor subunit B
  • Introduction
  • This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2; platelet-derived growth factor subunit B; PDGF subunit B; PDGF, B chain; becaplermin; epididymis secretory sperm binding protein; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor, beta polypeptide (oncogene SIS); proto-oncogene c-Sis

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