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Magic™ Antibody Discovery - Mouse PD-L1 / B7-H1 Membrane Protein, Partial, -hIgG1 Fc -Avi tag, [Biotin] (CAT#: MP1462F)

Datasheet
This membrane protein is Mouse PD-L1 / B7-H1 (19-238). It has been tested in SDS-PGAE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • PD-L1 / B7-H1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 53.2 kDa. The protein migrates as 65-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Phe 19 - Thr 238 (Accession # NP_068693)

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PGAE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc at the C-terminus, followed by a Avi tag
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Conjugation
  • Biotin
  • Purity
  • >95% as determined by SDS-PAGE
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, (pH7.5). Trehalose is added as protectant before lyophilization.

    Please contact us for customized formulation or product form if needed.

Target

  • Target Protein
  • PD-L1 / B7-H1
  • Full Name
  • CD274 antigen
  • Introduction
  • The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis.
  • Alternative Names
  • PD-; B7h1; Pdl1; Pdcd1l; Pdcd1l1; Pdcd1lg1; A530045L16Rik; programmed cell death 1 ligand 1; B7 homolog 1; PDCD1 ligand 1

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