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Magic™ Antibody Discovery - Rabbit OX40 / TNFRSF4 / CD134 (20-210) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0745F)

Datasheet
This membrane protein is Rabbit OX40 / TNFRSF4 / CD134 (20-210). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Rabbit
  • Target Protein
  • OX40 / TNFRSF4 / CD134
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 47.3 kDa. As a result of different glycosylation, the protein migrates as 48 kDa and 68 kDa under reducing (R) condition, and 120-135 kDa under non-reducing (NR) condition (SDS-PAGE).
  • Sequence
  • AA Val 20 - Pro 210 (Accession # P15725).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • OX40 / TNFRSF4 / CD134
  • Full Name
  • TNF superfamily member 4
  • Introduction
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
  • Alternative Names
  • TNLG2B; tumor necrosis factor ligand superfamily member 4; tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa); tumor necrosis factor ligand 2B; tumor necrosis factor superfamily member 4

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